Potential Antagonists of Excitatory Amino Acids and Anticonvulsants: Some Heterocyclic (±)-Pyrrolidine-2-carboxamides

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Title:Potential Antagonists of Excitatory Amino Acids and Anticonvulsants: Some Heterocyclic (±)-Pyrrolidine-2-carboxamides
Creators:
Valenta, Vladimír
Dobrovský, Karel
Krejčí, Ivan
Polívka, Zdeněk
Journal or Publication Title:
Collection of Czechoslovak Chemical Communications, 61, 7, pp. 1077-1084
Uncontrolled Keywords:Anticonvulsants, Excitatory amino acids, Pyrrolidine-2-carboxamides

Abstract

The benzylpyrrolidine amides <strong>1a-1d</strong>, <strong>3a-3e</strong>, <strong>5a</strong>, and <strong>5b</strong> were prepared from <i>N</i>-benzyl-L-proline methyl ester with corresponding diamines. Compounds <strong>2a-2d</strong>, <strong>4b</strong>, and <strong>4e</strong> have similarly been synthesized from L-proline methyl ester and the corresponding diamines in refluxing methanol. In both cases, the reactions were accompanied by racemization. Prepared amides were transformed to salts, suitable for pharmacological testing (hydrogen maleates, hydrogen oxalates and hydrochlorides). The products were tested by selected methods of biochemical and behavioural pharmacology. <p>

Title:Potential Antagonists of Excitatory Amino Acids and Anticonvulsants: Some Heterocyclic (±)-Pyrrolidine-2-carboxamides
Creators:
Valenta, Vladimír
Dobrovský, Karel
Krejčí, Ivan
Polívka, Zdeněk
Uncontrolled Keywords:Anticonvulsants, Excitatory amino acids, Pyrrolidine-2-carboxamides
Divisions:Life and Chemical Sciences > Institute of Organic Chemistry and Biochemistry > Collection of Czechoslovak Chemical Communications
Journal or Publication Title:Collection of Czechoslovak Chemical Communications
Volume:61
Number:7
Page Range:pp. 1077-1084
ISSN:0010-0765
E-ISSN:1212-6950
Publisher:Institute of Organic Chemistry and Biochemistry
Related URLs:
URLURL Type
http://dx.doi.org/10.1135/cccc19961077UNSPECIFIED
ID Code:1012
Item Type:Article
Deposited On:06 Feb 2009 17:05
Last Modified:06 Feb 2009 16:05

Citation

Valenta, Vladimír; Dobrovský, Karel; Krejčí, Ivan; Polívka, Zdeněk (1996) Potential Antagonists of Excitatory Amino Acids and Anticonvulsants: Some Heterocyclic (±)-Pyrrolidine-2-carboxamides. Collection of Czechoslovak Chemical Communications, 61 (7). pp. 1077-1084. ISSN 0010-0765

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