Synthesis of New L-Proline Amides with Anticonvulsive Effect

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Title:Synthesis of New L-Proline Amides with Anticonvulsive Effect
Creators:
Šilhánková, Alexandra
Šindelář, Karel
Dobrovský, Karel
Krejčí, Ivan
Hodková, Jarmila
Polívka, Zdeněk
Journal or Publication Title:
Collection of Czechoslovak Chemical Communications, 61, 7, pp. 1085-1092
Uncontrolled Keywords:Amines reaction, Amides preparation, Amino acids reaction, Anticonvulsive effect

Abstract

Series of heterocyclic L-proline amides were prepared from BOC-L-proline and heterocyclic amines (mostly substituted piperazines and morpholines) via active ester with hydroxysuccinimide. 4-(4-Fluorobenzoyl)piperidine afforded L-proline 4-(4-(4-(4-fluorobenzoyl)piperidin-1-yl)benzoyl)piperidine (<strong>7b</strong>) simultaneously with expected L-proline 4-(4-fluorobenzoyl)piperidide (<strong>7a</strong>). D-Proline <i>N</i>-(3-(4-(3-chlorophenyl)piperazin-1-yl)propyl)amide (<strong>2</strong>) was prepared starting from D-proline. The amides were tested by methods of biochemical and behavioural pharmacology.

Title:Synthesis of New L-Proline Amides with Anticonvulsive Effect
Creators:
Šilhánková, Alexandra
Šindelář, Karel
Dobrovský, Karel
Krejčí, Ivan
Hodková, Jarmila
Polívka, Zdeněk
Uncontrolled Keywords:Amines reaction, Amides preparation, Amino acids reaction, Anticonvulsive effect
Divisions:Life and Chemical Sciences > Institute of Organic Chemistry and Biochemistry > Collection of Czechoslovak Chemical Communications
Journal or Publication Title:Collection of Czechoslovak Chemical Communications
Volume:61
Number:7
Page Range:pp. 1085-1092
ISSN:0010-0765
E-ISSN:1212-6950
Publisher:Institute of Organic Chemistry and Biochemistry
Related URLs:
URLURL Type
http://dx.doi.org/10.1135/cccc19961085UNSPECIFIED
ID Code:1013
Item Type:Article
Deposited On:06 Feb 2009 17:05
Last Modified:06 Feb 2009 16:05

Citation

Šilhánková, Alexandra; Šindelář, Karel; Dobrovský, Karel; Krejčí, Ivan; Hodková, Jarmila; Polívka, Zdeněk (1996) Synthesis of New L-Proline Amides with Anticonvulsive Effect. Collection of Czechoslovak Chemical Communications, 61 (7). pp. 1085-1092. ISSN 0010-0765

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