Synthesis and Antituberculotic Properties of Some Substituted Pyrazinecarbothioamides

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Title:Synthesis and Antituberculotic Properties of Some Substituted Pyrazinecarbothioamides
Creators:
Doležal, Martin
Hartl, Jiří
Lyčka, Antonín
Buchta, Vladimír
Odlerová, Želmíra
Journal or Publication Title:
Collection of Czechoslovak Chemical Communications, 61, 7, pp. 1102-1108
Uncontrolled Keywords:Antituberculotic activity, Antifungal activity, Structure-activity relationships, Substituted aminopyrazinecarbothioamides

Abstract

A series of <i>N</i>-substituted 3-amino-5-thiocarbamoyl-2-pyrazinecarboxamides was prepared. The structure of compounds was confirmed by elemental analysis, IR and <sup>1</sup>H NMR spectra. The results of in vitro antifugal and antimycobacterial susceptibility testing shown no activity against pathogenic fungi and some effect on mycobacteria. The highest antituberculotic activity (MIC within 25-50 mg ml<sup>-1</sup>) against <i>Mycobacterium tuberculosis</i> and other mycobacterial strains in this series was shown by 3-(3-hydroxyphenylamino)-5-thiocarbamoyl-2-pyrazinecarboxamide. The antituberculotic activity of these compounds is mostly influenced by the presence of the thioamide moiety.

Title:Synthesis and Antituberculotic Properties of Some Substituted Pyrazinecarbothioamides
Creators:
Doležal, Martin
Hartl, Jiří
Lyčka, Antonín
Buchta, Vladimír
Odlerová, Želmíra
Uncontrolled Keywords:Antituberculotic activity, Antifungal activity, Structure-activity relationships, Substituted aminopyrazinecarbothioamides
Divisions:Life and Chemical Sciences > Institute of Organic Chemistry and Biochemistry > Collection of Czechoslovak Chemical Communications
Journal or Publication Title:Collection of Czechoslovak Chemical Communications
Volume:61
Number:7
Page Range:pp. 1102-1108
ISSN:0010-0765
E-ISSN:1212-6950
Publisher:Institute of Organic Chemistry and Biochemistry
Related URLs:
URLURL Type
http://dx.doi.org/10.1135/cccc19961102UNSPECIFIED
ID Code:1015
Item Type:Article
Deposited On:06 Feb 2009 17:05
Last Modified:06 Feb 2009 16:05

Citation

Doležal, Martin; Hartl, Jiří; Lyčka, Antonín; Buchta, Vladimír; Odlerová, Želmíra (1996) Synthesis and Antituberculotic Properties of Some Substituted Pyrazinecarbothioamides. Collection of Czechoslovak Chemical Communications, 61 (7). pp. 1102-1108. ISSN 0010-0765

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