N-1-Trimethylsilyl Derivatives of Ergot Alkaloids

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Title:N-1-Trimethylsilyl Derivatives of Ergot Alkaloids
Creators:
Křen, Vladimír
Sedmera, Petr
Journal or Publication Title:
Collection of Czechoslovak Chemical Communications, 61, 8, pp. 1248-1253
Uncontrolled Keywords:Clavines, Trimethylsilyl derivatives, <i>N</i>-Glycosylation, Ergot alkaloids

Abstract

<i>N</i>-1-Trimethylsilyl derivatives of five different suitably protected parent ergot (clavine) alkaloids (agroclavine <strong>1a</strong>, elymoclavine <strong>2a</strong>, lysergol <strong>3a</strong>, lysergene <strong>4a</strong>, and 9,10-dihydrolysergol <strong>5a</strong>) were prepared in 47-94% yields by refluxing the (protected) parent compounds with <i>N</i>-methyl-<i>N</i>-(trimethylsilyl)trifluoroacetamide in acetonitrile under nitrogen atmosphere.

Title:N-1-Trimethylsilyl Derivatives of Ergot Alkaloids
Creators:
Křen, Vladimír
Sedmera, Petr
Uncontrolled Keywords:Clavines, Trimethylsilyl derivatives, <i>N</i>-Glycosylation, Ergot alkaloids
Divisions:Life and Chemical Sciences > Institute of Organic Chemistry and Biochemistry > Collection of Czechoslovak Chemical Communications
Journal or Publication Title:Collection of Czechoslovak Chemical Communications
Volume:61
Number:8
Page Range:pp. 1248-1253
ISSN:0010-0765
E-ISSN:1212-6950
Publisher:Institute of Organic Chemistry and Biochemistry
Related URLs:
URLURL Type
http://dx.doi.org/10.1135/cccc19961248UNSPECIFIED
ID Code:1030
Item Type:Article
Deposited On:06 Feb 2009 17:05
Last Modified:06 Feb 2009 16:06

Citation

Křen, Vladimír; Sedmera, Petr (1996) N-1-Trimethylsilyl Derivatives of Ergot Alkaloids. Collection of Czechoslovak Chemical Communications, 61 (8). pp. 1248-1253. ISSN 0010-0765

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