Synthesis and Resolution of Racemic 2-Amino-2'-hydroxy-1,1'-binaphthyl

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Title:Synthesis and Resolution of Racemic 2-Amino-2'-hydroxy-1,1'-binaphthyl
Creators:
Smrčina, Martin
Vyskočil, Štěpán
Polívková, Jana
Poláková, Jana
Kočovský, Pavel
Journal or Publication Title:
Collection of Czechoslovak Chemical Communications, 61, 10, pp. 1520-1524
Uncontrolled Keywords:Resolution, Binaphthyls, Oxidative coupling

Abstract

The title compound <strong>3</strong> has been prepared via a highly selective, Cu(II)-mediated cross-coupling of 2-aminonaphthalene <strong>1</strong> and 2-naphthol <strong>2</strong> and resolved into enantiomers via crystallization of diastereoisomeric salts with (1<i>S</i>)-(+)-10-camphorsulfonic acid. The method has been optimized and the use of chromatography eliminated.

Title:Synthesis and Resolution of Racemic 2-Amino-2'-hydroxy-1,1'-binaphthyl
Creators:
Smrčina, Martin
Vyskočil, Štěpán
Polívková, Jana
Poláková, Jana
Kočovský, Pavel
Uncontrolled Keywords:Resolution, Binaphthyls, Oxidative coupling
Divisions:Life and Chemical Sciences > Institute of Organic Chemistry and Biochemistry > Collection of Czechoslovak Chemical Communications
Journal or Publication Title:Collection of Czechoslovak Chemical Communications
Volume:61
Number:10
Page Range:pp. 1520-1524
ISSN:0010-0765
E-ISSN:1212-6950
Publisher:Institute of Organic Chemistry and Biochemistry
Related URLs:
URLURL Type
http://dx.doi.org/10.1135/cccc19961520UNSPECIFIED
ID Code:1055
Item Type:Article
Deposited On:06 Feb 2009 17:06
Last Modified:06 Feb 2009 16:06

Citation

Smrčina, Martin; Vyskočil, Štěpán; Polívková, Jana; Poláková, Jana; Kočovský, Pavel (1996) Synthesis and Resolution of Racemic 2-Amino-2'-hydroxy-1,1'-binaphthyl. Collection of Czechoslovak Chemical Communications, 61 (10). pp. 1520-1524. ISSN 0010-0765

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