Synthesis of New [1,3]Diazaheterocyclo[2',1':2,3][1,3,5]thiadiazino[4,5-f]purine Ring Systems

[img]PDF - Authorized users only
Language: English
36Kb
Title:Synthesis of New [1,3]Diazaheterocyclo[2',1':2,3][1,3,5]thiadiazino[4,5-f]purine Ring Systems
Creators:
Hesek, Dušan
Rybár, Alfonz
Alföldi, Juraj
Bella, Juraj
Pätoprstý, Vladimír
Journal or Publication Title:
Collection of Czechoslovak Chemical Communications, 61, 11, pp. 1642-1646
Uncontrolled Keywords:[1,3,5]Thiadiazino[4,5-<i>f</i>]purinediones, Annelation reactions

Abstract

A simple method for preparation of the title ring systems <strong>3a-3d</strong> starting from 7-chloromethyl-8-chloro-1,3-dimethyl-7<i>H</i>-purine-2,6(1<i>H</i>,3<i>H</i>)-dione (<strong>1</strong>) and cyclic isothioureas <strong>2</strong> is described. First, alkylation of the mercapto group of compound <strong>2</strong> took place to give 7-isothiuronium derivative <strong>5</strong>, which in turn cyclized to the final product <strong>3</strong> in alkaline medium.

Title:Synthesis of New [1,3]Diazaheterocyclo[2',1':2,3][1,3,5]thiadiazino[4,5-f]purine Ring Systems
Creators:
Hesek, Dušan
Rybár, Alfonz
Alföldi, Juraj
Bella, Juraj
Pätoprstý, Vladimír
Uncontrolled Keywords:[1,3,5]Thiadiazino[4,5-<i>f</i>]purinediones, Annelation reactions
Divisions:Life and Chemical Sciences > Institute of Organic Chemistry and Biochemistry > Collection of Czechoslovak Chemical Communications
Journal or Publication Title:Collection of Czechoslovak Chemical Communications
Volume:61
Number:11
Page Range:pp. 1642-1646
ISSN:0010-0765
E-ISSN:1212-6950
Publisher:Institute of Organic Chemistry and Biochemistry
Related URLs:
URLURL Type
http://dx.doi.org/10.1135/cccc19961642UNSPECIFIED
ID Code:1067
Item Type:Article
Deposited On:06 Feb 2009 17:06
Last Modified:06 Feb 2009 16:06

Citation

Hesek, Dušan; Rybár, Alfonz; Alföldi, Juraj; Bella, Juraj; Pätoprstý, Vladimír (1996) Synthesis of New [1,3]Diazaheterocyclo[2',1':2,3][1,3,5]thiadiazino[4,5-f]purine Ring Systems. Collection of Czechoslovak Chemical Communications, 61 (11). pp. 1642-1646. ISSN 0010-0765

Repository Staff Only: item control page