Conformational Studies on Diribonucleoside Monophosphate Analogs Containing a Nonisosteric, Isopolar, Phosphonate-Based Internucleotide Linkage

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Title:Conformational Studies on Diribonucleoside Monophosphate Analogs Containing a Nonisosteric, Isopolar, Phosphonate-Based Internucleotide Linkage
Creators:
Zajíček, Jaroslav
Rosenberg, Ivan
Liboska, Radek
Točík, Zdeněk
Fazakerley, G. Victor
Guschlbauer, Wilhelm
Holý, Antonín
Journal or Publication Title:
Collection of Czechoslovak Chemical Communications, 62, 1, pp. 83-98
Uncontrolled Keywords:Conformation, Phosphonates, Diribonucleotide analogs

Abstract

Two types of (2'-5') and (3'-5') isomers of phosphonate analogs of diribonucleotides derived from 2'-, 3'- or 5'-<i>O</i>-phosphonomethyl ribonucleosides, that differ in the position of methylene group in the phosphonate internucleotide linkage, have been studied in aqueous solution by NMR techniques in order to compare their basic structural features with those of the natural (3'-5') diribonucleotides. Despite the additional methylene group in the ribose-phosphate backbone, dinucleoside phosphonates are structurally and conformationally very similar to their natural counterparts.

Title:Conformational Studies on Diribonucleoside Monophosphate Analogs Containing a Nonisosteric, Isopolar, Phosphonate-Based Internucleotide Linkage
Creators:
Zajíček, Jaroslav
Rosenberg, Ivan
Liboska, Radek
Točík, Zdeněk
Fazakerley, G. Victor
Guschlbauer, Wilhelm
Holý, Antonín
Uncontrolled Keywords:Conformation, Phosphonates, Diribonucleotide analogs
Divisions:Life and Chemical Sciences > Institute of Organic Chemistry and Biochemistry > Collection of Czechoslovak Chemical Communications
Journal or Publication Title:Collection of Czechoslovak Chemical Communications
Volume:62
Number:1
Page Range:pp. 83-98
ISSN:0010-0765
E-ISSN:1212-6950
Publisher:Institute of Organic Chemistry and Biochemistry
Related URLs:
URLURL Type
http://dx.doi.org/10.1135/cccc19970083UNSPECIFIED
ID Code:1097
Item Type:Article
Deposited On:06 Feb 2009 17:06
Last Modified:06 Feb 2009 16:06

Citation

Zajíček, Jaroslav; Rosenberg, Ivan; Liboska, Radek; Točík, Zdeněk; Fazakerley, G. Victor; Guschlbauer, Wilhelm; Holý, Antonín (1997) Conformational Studies on Diribonucleoside Monophosphate Analogs Containing a Nonisosteric, Isopolar, Phosphonate-Based Internucleotide Linkage. Collection of Czechoslovak Chemical Communications, 62 (1). pp. 83-98. ISSN 0010-0765

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