Heterogeneous Physico-Chemical Interactions Following Electrode Reaction: Interaction of Folates with Thiols

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Title:Heterogeneous Physico-Chemical Interactions Following Electrode Reaction: Interaction of Folates with Thiols
Creators:
Heyrovský, Michael
Prokopová, Barbora
Journal or Publication Title:
Collection of Czechoslovak Chemical Communications, 62, 2, pp. 172-184
Uncontrolled Keywords:Weak interactions, Thiols, Voltammetry, Heterogeneous medium, Folates

Abstract

Folates do not react chemically with thiols in solution, however, they cause shifts of voltammetric reversible reduction peaks of disulfides towards positive potentials. This is explained as due to the formation of adducts between folates and thiols at the electrode surface. Analogous shifts, but towards negative potentials, were observed with the voltammetric reversible oxidation peak of a reduced form of folic acid after addition of thiols, and were ascribed to the same cause. According to this interpretation the shifts would provide a measure of free enthalpy of the weak interaction between the two partners and the electrode. It is suggested that the observed effect could serve as a simplified model of processes which occur between folates and proteins in the microheterogeneous structure of the living matter.

Title:Heterogeneous Physico-Chemical Interactions Following Electrode Reaction: Interaction of Folates with Thiols
Creators:
Heyrovský, Michael
Prokopová, Barbora
Uncontrolled Keywords:Weak interactions, Thiols, Voltammetry, Heterogeneous medium, Folates
Divisions:Life and Chemical Sciences > Institute of Organic Chemistry and Biochemistry > Collection of Czechoslovak Chemical Communications
Journal or Publication Title:Collection of Czechoslovak Chemical Communications
Volume:62
Number:2
Page Range:pp. 172-184
ISSN:0010-0765
E-ISSN:1212-6950
Publisher:Institute of Organic Chemistry and Biochemistry
Related URLs:
URLURL Type
http://dx.doi.org/10.1135/cccc19970172UNSPECIFIED
ID Code:1105
Item Type:Article
Deposited On:06 Feb 2009 17:06
Last Modified:06 Feb 2009 16:06

Citation

Heyrovský, Michael; Prokopová, Barbora (1997) Heterogeneous Physico-Chemical Interactions Following Electrode Reaction: Interaction of Folates with Thiols. Collection of Czechoslovak Chemical Communications, 62 (2). pp. 172-184. ISSN 0010-0765

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