A New Pharmacophore of Potential Antimycobacterial Activity: The Disulfide Group in the Ring of Alicyclic Compounds

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Title:A New Pharmacophore of Potential Antimycobacterial Activity: The Disulfide Group in the Ring of Alicyclic Compounds
Creators:
Stachel, Hans-Dietrich
Odlerová, Želmíra
Waisser, Karel
Journal or Publication Title:
Collection of Czechoslovak Chemical Communications, 62, 3, pp. 510-515
Uncontrolled Keywords:Free-Wilson analysis, Structure-activity relationships, Antimycobacterial activity, 2,3-Dithiabicyclo[3.3.0]octa-4,8-dienes

Abstract

A series of thirty 2,3-dithiabicyclo[3.3.0]octa-4,8-diene derivatives was examined for antimycobacterial activity against <i>Mycobacterium tuberculosis</i>, <i>M. kansasii</i>, <i>M. avium</i>, and <i>M. fortuitum</i>. The structure-activity relationships were analysed by Free-Wilson method. The authors consider the disulfide moiety to be the pharmacophore of antimycobacterial activity. To verify the idea, several other monocyclic sulfides, 3,4-dihydro-1,2-dithiolane derivatives, were also evaluated.

Title:A New Pharmacophore of Potential Antimycobacterial Activity: The Disulfide Group in the Ring of Alicyclic Compounds
Creators:
Stachel, Hans-Dietrich
Odlerová, Želmíra
Waisser, Karel
Uncontrolled Keywords:Free-Wilson analysis, Structure-activity relationships, Antimycobacterial activity, 2,3-Dithiabicyclo[3.3.0]octa-4,8-dienes
Divisions:Life and Chemical Sciences > Institute of Organic Chemistry and Biochemistry > Collection of Czechoslovak Chemical Communications
Journal or Publication Title:Collection of Czechoslovak Chemical Communications
Volume:62
Number:3
Page Range:pp. 510-515
ISSN:0010-0765
E-ISSN:1212-6950
Publisher:Institute of Organic Chemistry and Biochemistry
Related URLs:
URLURL Type
http://dx.doi.org/10.1135/cccc19970510UNSPECIFIED
ID Code:1135
Item Type:Article
Deposited On:06 Feb 2009 17:06
Last Modified:06 Feb 2009 16:07

Citation

Stachel, Hans-Dietrich; Odlerová, Želmíra; Waisser, Karel (1997) A New Pharmacophore of Potential Antimycobacterial Activity: The Disulfide Group in the Ring of Alicyclic Compounds. Collection of Czechoslovak Chemical Communications, 62 (3). pp. 510-515. ISSN 0010-0765

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