Inhibition of Plasma Cholinesterase by O-Alkylfluorophosphonates

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Title:Inhibition of Plasma Cholinesterase by O-Alkylfluorophosphonates
Creators:
Cabal, Jiří
Kassa, Jiří
Patočka, Jiří
Journal or Publication Title:
Collection of Czechoslovak Chemical Communications, 62, 3, pp. 521-526
Uncontrolled Keywords:Soman, Acetylcholinesterase, Inhibitors, Sarin

Abstract

Inhibition of plasma cholinesterase by three methylfluorophosphonates (MFF), sarin, soman and cyclosin, and by the products of their hydrolysis and alcoholysis was examined. Inhibition by phosphonic acids and by methyl esters derived from MFF was purely competitive while that by MFF was irreversible. The rate of phosphorylation of cholinesterase by MFF differs, depending on the structure of the alkoxy group in the MFF and decreases in the sequence soman-sarin-cyclosin. The affinity values of MFF, phosphonic acids and methyl esters of phosphonic acid for cholinesterase are comparable. The <i>in vitro</i> kinetic parameters suggest that plasma cholinesterase might act as a natural detoxicating agent in cases of poisoning with the above inhibitors of acetylcholinesterase.

Title:Inhibition of Plasma Cholinesterase by O-Alkylfluorophosphonates
Creators:
Cabal, Jiří
Kassa, Jiří
Patočka, Jiří
Uncontrolled Keywords:Soman, Acetylcholinesterase, Inhibitors, Sarin
Divisions:Life and Chemical Sciences > Institute of Organic Chemistry and Biochemistry > Collection of Czechoslovak Chemical Communications
Journal or Publication Title:Collection of Czechoslovak Chemical Communications
Volume:62
Number:3
Page Range:pp. 521-526
ISSN:0010-0765
E-ISSN:1212-6950
Publisher:Institute of Organic Chemistry and Biochemistry
Related URLs:
URLURL Type
http://dx.doi.org/10.1135/cccc19970521UNSPECIFIED
ID Code:1137
Item Type:Article
Deposited On:06 Feb 2009 17:06
Last Modified:06 Feb 2009 16:07

Citation

Cabal, Jiří; Kassa, Jiří; Patočka, Jiří (1997) Inhibition of Plasma Cholinesterase by O-Alkylfluorophosphonates. Collection of Czechoslovak Chemical Communications, 62 (3). pp. 521-526. ISSN 0010-0765

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