Synthesis of Novel 4-Amino-5-(disubstituted amino)-2-phenyl-2H-pyridazin-3-ones

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Title:Synthesis of Novel 4-Amino-5-(disubstituted amino)-2-phenyl-2H-pyridazin-3-ones
Creators:
Konečný, Václav
Žúžiová, Jozefína
Kováč, Štefan
Liptaj, Tibor
Journal or Publication Title:
Collection of Czechoslovak Chemical Communications, 62, 5, pp. 800-808
Uncontrolled Keywords:2<i>H</i>-Pyridazin-3-ones, Pesticidal activity, Diazines

Abstract

Substituted 4-amino-2-phenyl-2<i>H</i>-pyridazin-3-ones <strong>5a-5j</strong> have been prepared from 4-amino-5-chloro-2-phenyl-2H-pyridazin-3-one <strong>1</strong> which on reactions with acetyl chloride or acetic anhydride gives 4-acetylamino derivative <strong>2</strong> or 4-diacetylamino derivative <strong>3</strong>, respectively. Derivatives <strong>2</strong> and <strong>3</strong> with dialkylamines and cyclic amines yielded appropriate 4-acetylamino-5-(disubstituted amino)-2-phenyl-2<i>H</i>-pyridazin-3-ones <strong>4a-4j</strong>. Subsequent alkaline hydrolysis of the acetylamino derivatives <strong>4a-4j</strong> let to the title compounds <strong>5a-5j</strong>, which were screened for pesticidal activity, but none of them reached activity of the used standards.

Title:Synthesis of Novel 4-Amino-5-(disubstituted amino)-2-phenyl-2H-pyridazin-3-ones
Creators:
Konečný, Václav
Žúžiová, Jozefína
Kováč, Štefan
Liptaj, Tibor
Uncontrolled Keywords:2<i>H</i>-Pyridazin-3-ones, Pesticidal activity, Diazines
Divisions:Life and Chemical Sciences > Institute of Organic Chemistry and Biochemistry > Collection of Czechoslovak Chemical Communications
Journal or Publication Title:Collection of Czechoslovak Chemical Communications
Volume:62
Number:5
Page Range:pp. 800-808
ISSN:0010-0765
E-ISSN:1212-6950
Publisher:Institute of Organic Chemistry and Biochemistry
Related URLs:
URLURL Type
http://dx.doi.org/10.1135/cccc19970800UNSPECIFIED
ID Code:1161
Item Type:Article
Deposited On:06 Feb 2009 17:07
Last Modified:06 Feb 2009 16:07

Citation

Konečný, Václav; Žúžiová, Jozefína; Kováč, Štefan; Liptaj, Tibor (1997) Synthesis of Novel 4-Amino-5-(disubstituted amino)-2-phenyl-2H-pyridazin-3-ones. Collection of Czechoslovak Chemical Communications, 62 (5). pp. 800-808. ISSN 0010-0765

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