Transport of Adefovir (PMEA) in Human T-Lymphoblastoid Cells

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Title:Transport of Adefovir (PMEA) in Human T-Lymphoblastoid Cells
Creators:
Olšanská, Lenka
Cihlar, Tomas
Votruba, Ivan
Holý, Antonín
Journal or Publication Title:
Collection of Czechoslovak Chemical Communications, 62, 5, pp. 821-828
Uncontrolled Keywords:Human cells, Adefovir, Transport

Abstract

The uptake of [<sup>3</sup>H]PMEA by human T-lymphoblastoid cells (CCRF-CEM) apparently proceeds by fluid-phase endocytosis. The transport kinetics was shown to be nonconcentrative and nonsaturable. The uptake takes place even at a low temperature (4 °C), is strictly dependent on the intracellular level of ATP, is not substantially affected by cell suspension density and is not competitively inhibited by other PME derivatives.

Title:Transport of Adefovir (PMEA) in Human T-Lymphoblastoid Cells
Creators:
Olšanská, Lenka
Cihlar, Tomas
Votruba, Ivan
Holý, Antonín
Uncontrolled Keywords:Human cells, Adefovir, Transport
Divisions:Life and Chemical Sciences > Institute of Organic Chemistry and Biochemistry > Collection of Czechoslovak Chemical Communications
Journal or Publication Title:Collection of Czechoslovak Chemical Communications
Volume:62
Number:5
Page Range:pp. 821-828
ISSN:0010-0765
E-ISSN:1212-6950
Publisher:Institute of Organic Chemistry and Biochemistry
Related URLs:
URLURL Type
http://dx.doi.org/10.1135/cccc19970821UNSPECIFIED
ID Code:1164
Item Type:Article
Deposited On:06 Feb 2009 17:07
Last Modified:06 Feb 2009 16:07

Citation

Olšanská, Lenka; Cihlar, Tomas; Votruba, Ivan; Holý, Antonín (1997) Transport of Adefovir (PMEA) in Human T-Lymphoblastoid Cells. Collection of Czechoslovak Chemical Communications, 62 (5). pp. 821-828. ISSN 0010-0765

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