Prostanoids: Synthesis of Enantiomers of 15-Deoxy-16-hydroxy-16-methylprostaglandin E1

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Title:Prostanoids: Synthesis of Enantiomers of 15-Deoxy-16-hydroxy-16-methylprostaglandin E1
Creators:
Terinek, Miroslav
Kozmík, Václav
Paleček, Jaroslav
Journal or Publication Title:
Collection of Czechoslovak Chemical Communications, 62, 8, pp. 1325-1341
Uncontrolled Keywords:Enantiomeric resolution, Prostaglandins

Abstract

Four optically pure isomers of methyl 11,16-dihydroxy-16-methyl-9-oxoprost-13-enoate (<strong>1a</strong>-<strong>1d</strong>) were synthesized using an approach reverse to the classical Corey procedure, the key intermediates being the easily accessible (-)- and (+)-enantiomers of the Corey lactone, <strong>2a</strong> and <strong>2b</strong>.

Title:Prostanoids: Synthesis of Enantiomers of 15-Deoxy-16-hydroxy-16-methylprostaglandin E1
Creators:
Terinek, Miroslav
Kozmík, Václav
Paleček, Jaroslav
Uncontrolled Keywords:Enantiomeric resolution, Prostaglandins
Divisions:Life and Chemical Sciences > Institute of Organic Chemistry and Biochemistry > Collection of Czechoslovak Chemical Communications
Journal or Publication Title:Collection of Czechoslovak Chemical Communications
Volume:62
Number:8
Page Range:pp. 1325-1341
ISSN:0010-0765
E-ISSN:1212-6950
Publisher:Institute of Organic Chemistry and Biochemistry
Related URLs:
URLURL Type
http://dx.doi.org/10.1135/cccc19971325UNSPECIFIED
ID Code:1211
Item Type:Article
Deposited On:06 Feb 2009 17:07
Last Modified:06 Feb 2009 16:07

Citation

Terinek, Miroslav; Kozmík, Václav; Paleček, Jaroslav (1997) Prostanoids: Synthesis of Enantiomers of 15-Deoxy-16-hydroxy-16-methylprostaglandin E1. Collection of Czechoslovak Chemical Communications, 62 (8). pp. 1325-1341. ISSN 0010-0765

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