Synthesis and Antifungal Activity of New Indolylthiazinone Derivatives

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Title:Synthesis and Antifungal Activity of New Indolylthiazinone Derivatives
Creators:
Dzurilla, Milan
Kutschy, Peter
Tewari, Jalpa P.
Ružinský, Martin
Šenvický, Stanislav
Kováčik, Vladimír
Journal or Publication Title:
Collection of Czechoslovak Chemical Communications, 63, 1, pp. 94-102
Uncontrolled Keywords:Isothiocyanates, Antifungal activity, Indolylthiazinones, Thioureas, Thiazines, Indoles

Abstract

New 6-(indol-3-yl)-5,6-dihydro-4<i>H</i>-1,3-thiazin-4-one derivatives were prepared by boron trifluoride catalyzed intramolecular cyclization of <i>N</i>'-substituted <i>N</i>-[3-(indol-3-yl)propenoyl]thioureas and by the reaction of 3-(indol-3-yl)propenoyl isothiocyanate with sodium hydrogensulfide. Antifungal activity of the prepared compounds was studied using the fungi <i>Alternaria brassicae</i> and <i>Alternaria brassicicola</i>.

Title:Synthesis and Antifungal Activity of New Indolylthiazinone Derivatives
Creators:
Dzurilla, Milan
Kutschy, Peter
Tewari, Jalpa P.
Ružinský, Martin
Šenvický, Stanislav
Kováčik, Vladimír
Uncontrolled Keywords:Isothiocyanates, Antifungal activity, Indolylthiazinones, Thioureas, Thiazines, Indoles
Divisions:Life and Chemical Sciences > Institute of Organic Chemistry and Biochemistry > Collection of Czechoslovak Chemical Communications
Journal or Publication Title:Collection of Czechoslovak Chemical Communications
Volume:63
Number:1
Page Range:pp. 94-102
ISSN:0010-0765
E-ISSN:1212-6950
Publisher:Institute of Organic Chemistry and Biochemistry
Related URLs:
URLURL Type
http://dx.doi.org/10.1135/cccc19980094UNSPECIFIED
ID Code:1277
Item Type:Article
Deposited On:06 Feb 2009 17:08
Last Modified:06 Feb 2009 16:08

Citation

Dzurilla, Milan; Kutschy, Peter; Tewari, Jalpa P.; Ružinský, Martin; Šenvický, Stanislav; Kováčik, Vladimír (1998) Synthesis and Antifungal Activity of New Indolylthiazinone Derivatives. Collection of Czechoslovak Chemical Communications, 63 (1). pp. 94-102. ISSN 0010-0765

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