2,4-Dihydroxyacetophenone Derivatives as Antileukotrienics with a Multiple Activity Mechanism

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Title:2,4-Dihydroxyacetophenone Derivatives as Antileukotrienics with a Multiple Activity Mechanism
Creators:
Kuchař, Miroslav
Čulíková, Kateřina
Panajotovová, Vladimíra
Brunová, Bohumila
Jandera, Antonín
Kmoníček, Vojtěch
Journal or Publication Title:
Collection of Czechoslovak Chemical Communications, 63, 1, pp. 103-114
Uncontrolled Keywords:Antileukotrienic activity, 2,4-Dihydroxy-3-propylacetophenone derivatives, Antiasthmatic effect

Abstract

A series of 2,4-dihydroxy-3-propylacetophenone derivatives containing alkylthiobenzoic or arylacetic acid moiety was prepared. The antileukotrienic activity of the substances was assessed in terms of inhibition of the biosynthesis of LTB<sub>4</sub> and bonding to LTB<sub>4</sub> and LTD<sub>4</sub> receptors. Some of the substances were found to exert a complex antileukotrienic effect in all of the three tests. The compounds also displayed an antiinflammatory effect, as manifested by a significant inhibition of LTD<sub>4</sub>-induced bronchospasm.

Title:2,4-Dihydroxyacetophenone Derivatives as Antileukotrienics with a Multiple Activity Mechanism
Creators:
Kuchař, Miroslav
Čulíková, Kateřina
Panajotovová, Vladimíra
Brunová, Bohumila
Jandera, Antonín
Kmoníček, Vojtěch
Uncontrolled Keywords:Antileukotrienic activity, 2,4-Dihydroxy-3-propylacetophenone derivatives, Antiasthmatic effect
Divisions:Life and Chemical Sciences > Institute of Organic Chemistry and Biochemistry > Collection of Czechoslovak Chemical Communications
Journal or Publication Title:Collection of Czechoslovak Chemical Communications
Volume:63
Number:1
Page Range:pp. 103-114
ISSN:0010-0765
E-ISSN:1212-6950
Publisher:Institute of Organic Chemistry and Biochemistry
Related URLs:
URLURL Type
http://dx.doi.org/10.1135/cccc19980103UNSPECIFIED
ID Code:1278
Item Type:Article
Deposited On:06 Feb 2009 17:08
Last Modified:06 Feb 2009 16:08

Citation

Kuchař, Miroslav; Čulíková, Kateřina; Panajotovová, Vladimíra; Brunová, Bohumila; Jandera, Antonín; Kmoníček, Vojtěch (1998) 2,4-Dihydroxyacetophenone Derivatives as Antileukotrienics with a Multiple Activity Mechanism. Collection of Czechoslovak Chemical Communications, 63 (1). pp. 103-114. ISSN 0010-0765

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