Cholinesterase Reactivators Derived from Pyridine-2-carbaldoxime

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Title:Cholinesterase Reactivators Derived from Pyridine-2-carbaldoxime
Creators:
Bielavský, Jiří
Kassa, Jiří
Elsnerová, Iva
Dejmek, Luboš
Journal or Publication Title:
Collection of Czechoslovak Chemical Communications, 63, 2, pp. 199-204
Uncontrolled Keywords:Cholinesterase, Organophosphates, Reactivators, Pyridines, Pyridinium salts

Abstract

Monoquaternary reactivators of cholinesterase <strong>3a-3c</strong> were prepared by quaternization of substituted pyridine-2-carbaldoximes with an ester (<strong>1a</strong>, <strong>1b</strong>) or carbamoyl (<strong>2</strong>) function in position 4. A new bisquaternary reactivator, 4-carbamoyl-2'-[(hydroxyimino)methyl]-1,1'-(but-2-ene-1,4-diyl)bispyridinium salt (<strong>5</strong>), was derived from the unsubstituted pyridine-2-carbaldoxime. The compounds were characterized by UV spectra and ionization constants. The substances exhibit antidote effects in intoxications with organophosphate cholinesterase inhibitors.

Title:Cholinesterase Reactivators Derived from Pyridine-2-carbaldoxime
Creators:
Bielavský, Jiří
Kassa, Jiří
Elsnerová, Iva
Dejmek, Luboš
Uncontrolled Keywords:Cholinesterase, Organophosphates, Reactivators, Pyridines, Pyridinium salts
Divisions:Life and Chemical Sciences > Institute of Organic Chemistry and Biochemistry > Collection of Czechoslovak Chemical Communications
Journal or Publication Title:Collection of Czechoslovak Chemical Communications
Volume:63
Number:2
Page Range:pp. 199-204
ISSN:0010-0765
E-ISSN:1212-6950
Publisher:Institute of Organic Chemistry and Biochemistry
Related URLs:
URLURL Type
http://dx.doi.org/10.1135/cccc19980199UNSPECIFIED
ID Code:1287
Item Type:Article
Deposited On:06 Feb 2009 17:08
Last Modified:06 Feb 2009 16:08

Citation

Bielavský, Jiří; Kassa, Jiří; Elsnerová, Iva; Dejmek, Luboš (1998) Cholinesterase Reactivators Derived from Pyridine-2-carbaldoxime. Collection of Czechoslovak Chemical Communications, 63 (2). pp. 199-204. ISSN 0010-0765

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