New Perspectives for the Treatment of HIV Infections

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Title:New Perspectives for the Treatment of HIV Infections
Creators:
De Clercq, Erik
Journal or Publication Title:
Collection of Czechoslovak Chemical Communications, 63, 4, pp. 449-479
Uncontrolled Keywords:Nucleosides, Non-nucleoside reverse transcriptase inhibitors (NNRTIs), HIV, Nucleoside/nucleotide reverse transcriptase inhibitors (NRTIs), HIV protease inhibitors, AIDS, Reverse transcriptase inhibitors, Peptidomimetics, Nucleotides

Abstract

The HIV replicative cycle reveals several virus-specific events that could function as targets for chemotherapeutic intervention. The compounds that are presently available as anti-HIV drugs are targeted at either the substrate binding site of the reverse transcriptase (zidovudine, didanosine, zalcitabine, stavudine, lamivudine) or a non-substrate binding site of the reverse transcriptase (nevirapine, delavirdine), or the viral protease (saquinavir, ritonavir, indinavir, nelfinavir). Remarkable clinical efficacy has been observed with combinations of different reverse transcriptase inhibitors and protease inhibitors. It may be anticipated that with the advent of newer and more efficient compounds the effectiveness of HIV inhibition could still be improved upon and the prospects for a definitive cure of the disease may be accomplished. An account with 107 references.

Title:New Perspectives for the Treatment of HIV Infections
Creators:
De Clercq, Erik
Uncontrolled Keywords:Nucleosides, Non-nucleoside reverse transcriptase inhibitors (NNRTIs), HIV, Nucleoside/nucleotide reverse transcriptase inhibitors (NRTIs), HIV protease inhibitors, AIDS, Reverse transcriptase inhibitors, Peptidomimetics, Nucleotides
Divisions:Life and Chemical Sciences > Institute of Organic Chemistry and Biochemistry > Collection of Czechoslovak Chemical Communications
Journal or Publication Title:Collection of Czechoslovak Chemical Communications
Volume:63
Number:4
Page Range:pp. 449-479
ISSN:0010-0765
E-ISSN:1212-6950
Publisher:Institute of Organic Chemistry and Biochemistry
Related URLs:
URLURL Type
http://dx.doi.org/10.1135/cccc19980449UNSPECIFIED
ID Code:1313
Item Type:Article
Deposited On:06 Feb 2009 17:08
Last Modified:06 Feb 2009 16:08

Citation

De Clercq, Erik (1998) New Perspectives for the Treatment of HIV Infections. Collection of Czechoslovak Chemical Communications, 63 (4). pp. 449-479. ISSN 0010-0765

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