Progress in Partial Synthesis of a Marine Secosterol from Gersemia fruticosa: Preparation of the Steroidal Core Unit

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Title:Progress in Partial Synthesis of a Marine Secosterol from Gersemia fruticosa: Preparation of the Steroidal Core Unit
Creators:
Kuhl, Alexander
Kreiser, Wolfgang
Journal or Publication Title:
Collection of Czechoslovak Chemical Communications, 63, 7, pp. 1007-1011
Uncontrolled Keywords:Cytotoxic effect, Seco sterols, Steroids, Soft coral

Abstract

The synthesis of the requisite protected steroidal core unit <strong>13</strong> <i>en route</i> to secosterol <strong>1</strong>, a cytotoxic constituent of the soft coral <i>Gersemia fruticosa</i>, is described. The conversion of the intermediate precursor <strong>3</strong> into <strong>13</strong> succeeds through oxidative side chain degradation, deoxygenation of C-12 <i>via</i> reductive desulfurization and cleavage of the C-ring moiety by ozonolysis.

Title:Progress in Partial Synthesis of a Marine Secosterol from Gersemia fruticosa: Preparation of the Steroidal Core Unit
Creators:
Kuhl, Alexander
Kreiser, Wolfgang
Uncontrolled Keywords:Cytotoxic effect, Seco sterols, Steroids, Soft coral
Divisions:Life and Chemical Sciences > Institute of Organic Chemistry and Biochemistry > Collection of Czechoslovak Chemical Communications
Journal or Publication Title:Collection of Czechoslovak Chemical Communications
Volume:63
Number:7
Page Range:pp. 1007-1011
ISSN:0010-0765
E-ISSN:1212-6950
Publisher:Institute of Organic Chemistry and Biochemistry
Related URLs:
URLURL Type
http://dx.doi.org/10.1135/cccc19981007UNSPECIFIED
ID Code:1359
Item Type:Article
Deposited On:06 Feb 2009 17:08
Last Modified:06 Feb 2009 16:08

Citation

Kuhl, Alexander; Kreiser, Wolfgang (1998) Progress in Partial Synthesis of a Marine Secosterol from Gersemia fruticosa: Preparation of the Steroidal Core Unit. Collection of Czechoslovak Chemical Communications, 63 (7). pp. 1007-1011. ISSN 0010-0765

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