Synthesis of 17β-Isoxazolyl Steroids and Spiro[steroid-17,2'-furanone]s

[img]PDF - Authorized users only
Language: English
77Kb
Title:Synthesis of 17β-Isoxazolyl Steroids and Spiro[steroid-17,2'-furanone]s
Creators:
Baranovsky, Alexander V.
Groen, Marinus B.
Groot, Aede de
Litvinovskaya, Raissa P.
Khripach, Vladimir A.
Journal or Publication Title:
Collection of Czechoslovak Chemical Communications, 63, 10, pp. 1564-1574
Uncontrolled Keywords:Isoxazoles, Steroids, Spiro[steroid-17,2'-furanone]s, Nitrile oxides, Steroidal spirofuranones

Abstract

Synthesis of 17β-isoxazolyl steroids and their transformations into the corresponding spiro[steroid-17,2'-furanone]s are described. The reaction sequence consists of the 1,3-dipolar cycloaddition of a nitrile oxide to mestrenol, dehydration, epoxidation or dihydroxylation, cleavage of the isoxazole moiety and cyclization of intermediate enamino ketones.

Title:Synthesis of 17β-Isoxazolyl Steroids and Spiro[steroid-17,2'-furanone]s
Creators:
Baranovsky, Alexander V.
Groen, Marinus B.
Groot, Aede de
Litvinovskaya, Raissa P.
Khripach, Vladimir A.
Uncontrolled Keywords:Isoxazoles, Steroids, Spiro[steroid-17,2'-furanone]s, Nitrile oxides, Steroidal spirofuranones
Divisions:Life and Chemical Sciences > Institute of Organic Chemistry and Biochemistry > Collection of Czechoslovak Chemical Communications
Journal or Publication Title:Collection of Czechoslovak Chemical Communications
Volume:63
Number:10
Page Range:pp. 1564-1574
ISSN:0010-0765
E-ISSN:1212-6950
Publisher:Institute of Organic Chemistry and Biochemistry
Related URLs:
URLURL Type
http://dx.doi.org/10.1135/cccc19981564UNSPECIFIED
ID Code:1402
Item Type:Article
Deposited On:06 Feb 2009 17:09
Last Modified:06 Feb 2009 16:09

Citation

Baranovsky, Alexander V.; Groen, Marinus B.; Groot, Aede de; Litvinovskaya, Raissa P.; Khripach, Vladimir A. (1998) Synthesis of 17β-Isoxazolyl Steroids and Spiro[steroid-17,2'-furanone]s. Collection of Czechoslovak Chemical Communications, 63 (10). pp. 1564-1574. ISSN 0010-0765

Repository Staff Only: item control page