Antineoplastic Agents 385. The Isolation and Structure of a Scalarane-Type Sesterterpene from the Indian Ocean Porifera Hyrtios erecta

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Title:Antineoplastic Agents 385. The Isolation and Structure of a Scalarane-Type Sesterterpene from the Indian Ocean Porifera Hyrtios erecta
Creators:
Pettit, George R.
Cichacz, Zbigniew A.
Tan, Rui
Herald, Delbert L.
Melody, Noeleen
Hoard, Michael S.
Doubek, Dennis L.
Hooper, John N. A.
Journal or Publication Title:
Collection of Czechoslovak Chemical Communications, 63, 10, pp. 1671-1677
Uncontrolled Keywords:Sesterterpenes, X-Ray diffraction, Terpenes, Natural products, Crystal structure, Scalorolides, Marine sponge, NMR spectroscopy

Abstract

Bioassay-guided separation techniques were employed to isolate (3.3·10<sup>-7</sup>% yield) a new murine P388 lymphocytic leukemia cell line inhibitor (ED<sub>50</sub> 2.9 μg/ml) 12-<i>O</i>-deacetyl-19-deoxyscalarin from extracts of the Republic of Maldives marine sponge <i>Hyrtios erecta</i>. The structure was deduced using high field 2D NMR and high resolution mass spectral methods and confirmed by X-ray crystal structure determination.

Title:Antineoplastic Agents 385. The Isolation and Structure of a Scalarane-Type Sesterterpene from the Indian Ocean Porifera Hyrtios erecta
Creators:
Pettit, George R.
Cichacz, Zbigniew A.
Tan, Rui
Herald, Delbert L.
Melody, Noeleen
Hoard, Michael S.
Doubek, Dennis L.
Hooper, John N. A.
Uncontrolled Keywords:Sesterterpenes, X-Ray diffraction, Terpenes, Natural products, Crystal structure, Scalorolides, Marine sponge, NMR spectroscopy
Divisions:Life and Chemical Sciences > Institute of Organic Chemistry and Biochemistry > Collection of Czechoslovak Chemical Communications
Journal or Publication Title:Collection of Czechoslovak Chemical Communications
Volume:63
Number:10
Page Range:pp. 1671-1677
ISSN:0010-0765
E-ISSN:1212-6950
Publisher:Institute of Organic Chemistry and Biochemistry
Related URLs:
URLURL Type
http://dx.doi.org/10.1135/cccc19981671UNSPECIFIED
ID Code:1412
Item Type:Article
Deposited On:06 Feb 2009 17:09
Last Modified:06 Feb 2009 16:09

Citation

Pettit, George R.; Cichacz, Zbigniew A.; Tan, Rui; Herald, Delbert L.; Melody, Noeleen; Hoard, Michael S.; Doubek, Dennis L.; Hooper, John N. A. (1998) Antineoplastic Agents 385. The Isolation and Structure of a Scalarane-Type Sesterterpene from the Indian Ocean Porifera Hyrtios erecta. Collection of Czechoslovak Chemical Communications, 63 (10). pp. 1671-1677. ISSN 0010-0765

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