Antituberculotic 4'-Cyclohexylthiobenzanilides: Combination of Free-Wilson Method in QSAR with Topliss Approach

[img]PDF - Authorized users only
Language: English
527Kb
Title:Antituberculotic 4'-Cyclohexylthiobenzanilides: Combination of Free-Wilson Method in QSAR with Topliss Approach
Creators:
Waisser, Karel
Kubicová, Lenka
Odlerová, Želmíra
Journal or Publication Title:
Collection of Czechoslovak Chemical Communications, 58, 1, pp. 205-212

Abstract

On the basis of a preliminary study of antimycobacterial activity of thiobenzanilides against <i>Mycobacterium kansasii</i>, a group of 4'-cyclohexylthiobenzanilids have been prepared which exhibit a significant activity against the microorganism mentioned. The whole set of 35 thiobenzanilides was tested with <i>Mycobacterium tuberculosis</i>, and on the basis of QSAR analysis conclusions have been made with regard to prognostics of structures suitable for further studies. The problem was solved by the method by Free and Wilson combined with the Topliss approach and by a Hansch type analysis.

Title:Antituberculotic 4'-Cyclohexylthiobenzanilides: Combination of Free-Wilson Method in QSAR with Topliss Approach
Creators:
Waisser, Karel
Kubicová, Lenka
Odlerová, Želmíra
Divisions:Life and Chemical Sciences > Institute of Organic Chemistry and Biochemistry > Collection of Czechoslovak Chemical Communications
Journal or Publication Title:Collection of Czechoslovak Chemical Communications
Volume:58
Number:1
Page Range:pp. 205-212
ISSN:0010-0765
E-ISSN:1212-6950
Publisher:Institute of Organic Chemistry and Biochemistry
Related URLs:
URLURL Type
http://dx.doi.org/10.1135/cccc19930205UNSPECIFIED
ID Code:142
Item Type:Article
Deposited On:06 Feb 2009 16:58
Last Modified:06 Feb 2009 15:58

Citation

Waisser, Karel; Kubicová, Lenka; Odlerová, Želmíra (1993) Antituberculotic 4'-Cyclohexylthiobenzanilides: Combination of Free-Wilson Method in QSAR with Topliss Approach. Collection of Czechoslovak Chemical Communications, 58 (1). pp. 205-212. ISSN 0010-0765

Repository Staff Only: item control page