Perfluoroalkylation of 6-Iodopurines by Trimethyl(perfluoroalkyl)silanes. Synthesis of 6-(Perfluoroalkyl)purine Bases, Nucleosides and Acyclic Nucleotide Analogues

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Title:Perfluoroalkylation of 6-Iodopurines by Trimethyl(perfluoroalkyl)silanes. Synthesis of 6-(Perfluoroalkyl)purine Bases, Nucleosides and Acyclic Nucleotide Analogues
Creators:
Hocek, Michal
Holý, Antonín
Journal or Publication Title:
Collection of Czechoslovak Chemical Communications, 64, 2, pp. 229-241
Uncontrolled Keywords:Purines, Nucleosides, Perfluoroalkylation, Cuprates, Cytostatic activity, Fluorinated compounds, Cross-coupling reactions, Trifluoromethylation

Abstract

A CuI/KF mediated perfluoroalkylation reaction of various 9-substituted 6-iodopurines <strong>1</strong> with trimethyl(trifluoromethyl)silane or heptafluoropropyl(trimethyl)silane was used for the synthesis of the corresponding 6-(trifluoromethyl)- and 6-(heptafluoropropyl)purine derivatives (purine bases, nucleosides and acyclic nucleotide analogues) in moderate to good yields. <p>

Title:Perfluoroalkylation of 6-Iodopurines by Trimethyl(perfluoroalkyl)silanes. Synthesis of 6-(Perfluoroalkyl)purine Bases, Nucleosides and Acyclic Nucleotide Analogues
Creators:
Hocek, Michal
Holý, Antonín
Uncontrolled Keywords:Purines, Nucleosides, Perfluoroalkylation, Cuprates, Cytostatic activity, Fluorinated compounds, Cross-coupling reactions, Trifluoromethylation
Divisions:Life and Chemical Sciences > Institute of Organic Chemistry and Biochemistry > Collection of Czechoslovak Chemical Communications
Journal or Publication Title:Collection of Czechoslovak Chemical Communications
Volume:64
Number:2
Page Range:pp. 229-241
ISSN:0010-0765
E-ISSN:1212-6950
Publisher:Institute of Organic Chemistry and Biochemistry
Related URLs:
URLURL Type
http://dx.doi.org/10.1135/cccc19990229UNSPECIFIED
ID Code:1472
Item Type:Article
Deposited On:06 Feb 2009 17:09
Last Modified:06 Feb 2009 16:09

Citation

Hocek, Michal; Holý, Antonín (1999) Perfluoroalkylation of 6-Iodopurines by Trimethyl(perfluoroalkyl)silanes. Synthesis of 6-(Perfluoroalkyl)purine Bases, Nucleosides and Acyclic Nucleotide Analogues. Collection of Czechoslovak Chemical Communications, 64 (2). pp. 229-241. ISSN 0010-0765

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