Synthesis of New Potential Bis-Intercalators Based on Chiral Pyridine-2,6-dicarboxamides

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Title:Synthesis of New Potential Bis-Intercalators Based on Chiral Pyridine-2,6-dicarboxamides
Creators:
Amr, Abd El-Galil
Abd El-Salam, Osama I.
Attia, Abd El-Hamid
Stibor, Ivan
Journal or Publication Title:
Collection of Czechoslovak Chemical Communications, 64, 2, pp. 288-298
Uncontrolled Keywords:Chiral intercalators, Amino acids, Pyridine-2,6-dicarboxamides, Antimicrobial activity, DNA intercalation, Naphthalimides

Abstract

Potential bis-intercalating compounds <i>N,N</i>-dibenzylidene-<i>N</i><sup>2</sup>,<i>N</i><sup>2'</sup>-(pyridine-2,6-dicarbonyl)- di(aminoacidhydrazides) <strong>4a</strong>-<strong>4j</strong>, <i>N,N'</i>-substituted pyridine-2,6-bis(carbohydrazides) <strong>5a</strong>-<strong>5d</strong> and <i>N,N'</i>-substituted <i>N</i><sup>2</sup><i>N</i><sup>2'</sup>-bis(pyridine-2,6-dicarbonyl)di(aminoacidhydrazides) <strong>6a-6g</strong>, both racemic and optically active, can be easily synthesized from pyridine-2,6-bis(carbohydrazide), natural amino acids and aromatic aldehydes or anhydrides of aromatic ortho-dicarboxylic acids.

Title:Synthesis of New Potential Bis-Intercalators Based on Chiral Pyridine-2,6-dicarboxamides
Creators:
Amr, Abd El-Galil
Abd El-Salam, Osama I.
Attia, Abd El-Hamid
Stibor, Ivan
Uncontrolled Keywords:Chiral intercalators, Amino acids, Pyridine-2,6-dicarboxamides, Antimicrobial activity, DNA intercalation, Naphthalimides
Divisions:Life and Chemical Sciences > Institute of Organic Chemistry and Biochemistry > Collection of Czechoslovak Chemical Communications
Journal or Publication Title:Collection of Czechoslovak Chemical Communications
Volume:64
Number:2
Page Range:pp. 288-298
ISSN:0010-0765
E-ISSN:1212-6950
Publisher:Institute of Organic Chemistry and Biochemistry
Related URLs:
URLURL Type
http://dx.doi.org/10.1135/cccc19990288UNSPECIFIED
ID Code:1476
Item Type:Article
Deposited On:06 Feb 2009 17:09
Last Modified:06 Feb 2009 16:09

Citation

Amr, Abd El-Galil; Abd El-Salam, Osama I.; Attia, Abd El-Hamid; Stibor, Ivan (1999) Synthesis of New Potential Bis-Intercalators Based on Chiral Pyridine-2,6-dicarboxamides. Collection of Czechoslovak Chemical Communications, 64 (2). pp. 288-298. ISSN 0010-0765

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