Ring-Opened Analogs of Indomethacin Affecting Human Neutrophil Functions

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Title:Ring-Opened Analogs of Indomethacin Affecting Human Neutrophil Functions
Creators:
Andreani, Aldo
Leoni, Alberto
Locatelli, Alessandra
Morigi, Rita
Rambaldi, Mirella
Gehret, Jean-Claude
Traniello, Serena
Cariani, Alessio
Spisani, Susanna
Journal or Publication Title:
Collection of Czechoslovak Chemical Communications, 64, 2, pp. 299-312
Uncontrolled Keywords:Inflammation, Thiazoles, Indomethacin, Imidazo[2,1-<i>b</i>]thiazoles, Neutrophil functions, Antiinflammatory agents

Abstract

A series of ring-opened analogs of indomethacin was synthesized and tested <i>in vitro</i> (at concentrations ranging from 10<sup>-9</sup> to 10<sup>-5</sup> mol/l) on human neutrophil functions. Two compounds lacking the carboxylic group were subjected to the same tests and one of these showed unexpected activity. Among the acidic derivatives, compound <strong>12</strong> bearing the same substituents as indomethacin <strong>10</strong> (methoxy and 4-chlorobenzoyl groups) was the most active: it significantly lowered neutrophil responses in all five bioassays and at the three concentrations considered. <p>

Title:Ring-Opened Analogs of Indomethacin Affecting Human Neutrophil Functions
Creators:
Andreani, Aldo
Leoni, Alberto
Locatelli, Alessandra
Morigi, Rita
Rambaldi, Mirella
Gehret, Jean-Claude
Traniello, Serena
Cariani, Alessio
Spisani, Susanna
Uncontrolled Keywords:Inflammation, Thiazoles, Indomethacin, Imidazo[2,1-<i>b</i>]thiazoles, Neutrophil functions, Antiinflammatory agents
Divisions:Life and Chemical Sciences > Institute of Organic Chemistry and Biochemistry > Collection of Czechoslovak Chemical Communications
Journal or Publication Title:Collection of Czechoslovak Chemical Communications
Volume:64
Number:2
Page Range:pp. 299-312
ISSN:0010-0765
E-ISSN:1212-6950
Publisher:Institute of Organic Chemistry and Biochemistry
Related URLs:
URLURL Type
http://dx.doi.org/10.1135/cccc19990299UNSPECIFIED
ID Code:1477
Item Type:Article
Deposited On:06 Feb 2009 17:09
Last Modified:06 Feb 2009 16:10

Citation

Andreani, Aldo; Leoni, Alberto; Locatelli, Alessandra; Morigi, Rita; Rambaldi, Mirella; Gehret, Jean-Claude; Traniello, Serena; Cariani, Alessio; Spisani, Susanna (1999) Ring-Opened Analogs of Indomethacin Affecting Human Neutrophil Functions. Collection of Czechoslovak Chemical Communications, 64 (2). pp. 299-312. ISSN 0010-0765

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