Intramolecular Mannich Reaction of 2-Oxotryptamines with Acetone Yielding Spiro[indole-3,3'-pyrrolidin]-2-ones

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Title:Intramolecular Mannich Reaction of 2-Oxotryptamines with Acetone Yielding Spiro[indole-3,3'-pyrrolidin]-2-ones
Creators:
Incze, Mária
Dörnyei, Gábor
Kajtár-Peredy, Mária
Szántay, Csaba
Journal or Publication Title:
Collection of Czechoslovak Chemical Communications, 64, 2, pp. 408-416
Uncontrolled Keywords:Intramolecular Mannich reaction, Cyclizations, Spirocyclic compounds, Indoles, Alkaloids, Pyrrolidines

Abstract

2-Oxotryptamines undergo intramolecular Mannich-type cyclization with acetone to give 2',2'-dimethylspiro[indole-3,3'-pyrrolidin]-2-ones. In presence of an alkylating reagent, this reaction gives the corresponding 1'-substituted products. <p>

Title:Intramolecular Mannich Reaction of 2-Oxotryptamines with Acetone Yielding Spiro[indole-3,3'-pyrrolidin]-2-ones
Creators:
Incze, Mária
Dörnyei, Gábor
Kajtár-Peredy, Mária
Szántay, Csaba
Uncontrolled Keywords:Intramolecular Mannich reaction, Cyclizations, Spirocyclic compounds, Indoles, Alkaloids, Pyrrolidines
Divisions:Life and Chemical Sciences > Institute of Organic Chemistry and Biochemistry > Collection of Czechoslovak Chemical Communications
Journal or Publication Title:Collection of Czechoslovak Chemical Communications
Volume:64
Number:2
Page Range:pp. 408-416
ISSN:0010-0765
E-ISSN:1212-6950
Publisher:Institute of Organic Chemistry and Biochemistry
Related URLs:
URLURL Type
http://dx.doi.org/10.1135/cccc19990408UNSPECIFIED
ID Code:1485
Item Type:Article
Deposited On:06 Feb 2009 17:09
Last Modified:06 Feb 2009 16:10

Citation

Incze, Mária; Dörnyei, Gábor; Kajtár-Peredy, Mária; Szántay, Csaba (1999) Intramolecular Mannich Reaction of 2-Oxotryptamines with Acetone Yielding Spiro[indole-3,3'-pyrrolidin]-2-ones. Collection of Czechoslovak Chemical Communications, 64 (2). pp. 408-416. ISSN 0010-0765

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