Erythrocyte Membrane Fluidity in Diabetics: Fluorescence Study

[img]PDF - Authorized users only
Language: English
47Kb
Title:Erythrocyte Membrane Fluidity in Diabetics: Fluorescence Study
Creators:
Jakuš, Vladimír
Fuhr, Uwe
Wörner, Wolfgang
Rietbrock, Norbert
Journal or Publication Title:
Collection of Czechoslovak Chemical Communications, 64, 3, pp. 548-552
Uncontrolled Keywords:Antiglycation therapy, Glycation, Diabetes, Membrane fluidity, Lipoic acid, Captopril, Erythrocytes, human, Penicillamine

Abstract

Erythrocyte membrane fluidity is changed in diabetic subjects with long-term complications. As membrane fluidity indicator, the mean steady-state fluorescence anisotropy was measured in 1,6-diphenylhexa-1,3,5-triene labelled erythrocyte membranes prepared from six control healthy donors and six poorly controlled diabetic subjects. Fluorescence anisotropy values of membranes prepared from erythrocytes of diabetic subjects were significantly higher than in control subjects. This indicates a decreased fluidity of membranes prepared from diabetic subjects. The decreased fluidity of diabetic membranes was raised by glycation inhibitors - penicillamine, captopril, and lipoic acid. <p>

Title:Erythrocyte Membrane Fluidity in Diabetics: Fluorescence Study
Creators:
Jakuš, Vladimír
Fuhr, Uwe
Wörner, Wolfgang
Rietbrock, Norbert
Uncontrolled Keywords:Antiglycation therapy, Glycation, Diabetes, Membrane fluidity, Lipoic acid, Captopril, Erythrocytes, human, Penicillamine
Divisions:Life and Chemical Sciences > Institute of Organic Chemistry and Biochemistry > Collection of Czechoslovak Chemical Communications
Journal or Publication Title:Collection of Czechoslovak Chemical Communications
Volume:64
Number:3
Page Range:pp. 548-552
ISSN:0010-0765
E-ISSN:1212-6950
Publisher:Institute of Organic Chemistry and Biochemistry
Related URLs:
URLURL Type
http://dx.doi.org/10.1135/cccc19990548UNSPECIFIED
ID Code:1497
Item Type:Article
Deposited On:06 Feb 2009 17:10
Last Modified:06 Feb 2009 16:10

Citation

Jakuš, Vladimír; Fuhr, Uwe; Wörner, Wolfgang; Rietbrock, Norbert (1999) Erythrocyte Membrane Fluidity in Diabetics: Fluorescence Study. Collection of Czechoslovak Chemical Communications, 64 (3). pp. 548-552. ISSN 0010-0765

Repository Staff Only: item control page