Electrochemical Oxidation of Probucol in Anhydrous Acetonitrile

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Title:Electrochemical Oxidation of Probucol in Anhydrous Acetonitrile
Creators:
Nesměrák, Karel
Němec, Ivan
Štícha, Martin
Gabriel, Jiří
Mirceski, Valentin
Journal or Publication Title:
Collection of Czechoslovak Chemical Communications, 64, 7, pp. 1100-1110
Uncontrolled Keywords:Metabolic oxidation, Potentiostatic coulometry, Radicals, Preparative electrolysis, Voltammetry, Electrochemistry, Probucol

Abstract

Electrochemical oxidation of probucol in anhydrous acetonitrile was studied as a model of the metabolic oxidation of the substance. The study was performed by DC voltammetry, potentiostatic coulometry, cyclic voltammetry and preparative electrolysis. Probucol gives a single anodic wave <i>E</i><sub>1/2</sub> = 0.92 V. Cyclic voltammetry showes that its electrooxidation proceeds by formation of probucol radical. 2,6-Di-<i>tert</i>-butyl-4-(isopropylsulfanyl)phenol, 2,6-di-<i>tert</i>-butyl-4-sulfanylphenol, 2,6-di-<i>tert</i>-butyl-4-methylphenol and 2,6-di-<i>tert</i>-butylphenol were isolated as products of electrochemical oxidation.

Title:Electrochemical Oxidation of Probucol in Anhydrous Acetonitrile
Creators:
Nesměrák, Karel
Němec, Ivan
Štícha, Martin
Gabriel, Jiří
Mirceski, Valentin
Uncontrolled Keywords:Metabolic oxidation, Potentiostatic coulometry, Radicals, Preparative electrolysis, Voltammetry, Electrochemistry, Probucol
Divisions:Life and Chemical Sciences > Institute of Organic Chemistry and Biochemistry > Collection of Czechoslovak Chemical Communications
Journal or Publication Title:Collection of Czechoslovak Chemical Communications
Volume:64
Number:7
Page Range:pp. 1100-1110
ISSN:0010-0765
E-ISSN:1212-6950
Publisher:Institute of Organic Chemistry and Biochemistry
Related URLs:
URLURL Type
http://dx.doi.org/10.1135/cccc19991100UNSPECIFIED
ID Code:1541
Item Type:Article
Deposited On:06 Feb 2009 17:10
Last Modified:06 Feb 2009 16:10

Citation

Nesměrák, Karel; Němec, Ivan; Štícha, Martin; Gabriel, Jiří; Mirceski, Valentin (1999) Electrochemical Oxidation of Probucol in Anhydrous Acetonitrile. Collection of Czechoslovak Chemical Communications, 64 (7). pp. 1100-1110. ISSN 0010-0765

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