Biological Function and Chemistry of Endothelin. A Review

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Title:Biological Function and Chemistry of Endothelin. A Review
Creators:
Hlaváček, Jan
Marcová, Renáta
Journal or Publication Title:
Collection of Czechoslovak Chemical Communications, 64, 8, pp. 1211-1252
Uncontrolled Keywords:Peptides, Peptide synthesis, Conformation analysis, Non peptide antagonists, Sarafotoxin, Endothelin, Vasoconstriction, Vasodilatation, Peptide antagonists

Abstract

The first part of this review deals with the biosynthesis and a biological function of strongly vasoactive peptides named endothelins (ETs) including vasoactive intestinal contractor. Where it was useful, snake venoms sarafotoxins which are structural endothelin derivatives, were also mentioned. In the second part, an attention is paid to structural basis of the ETs biological activity, with respect to alterations of amino acid residues in the parent peptides modifying the conformation and consequently the physico-chemical and biological properties in corresponding ETs analogs. Special attention is focussed on the area of ETs receptors and their interaction with peptide and non peptide agonists and antagonists, important in designing selective inhibitors of ETs receptors potentially applicable as drugs in a medicine. A review with 182 references. <p>

Title:Biological Function and Chemistry of Endothelin. A Review
Creators:
Hlaváček, Jan
Marcová, Renáta
Uncontrolled Keywords:Peptides, Peptide synthesis, Conformation analysis, Non peptide antagonists, Sarafotoxin, Endothelin, Vasoconstriction, Vasodilatation, Peptide antagonists
Divisions:Life and Chemical Sciences > Institute of Organic Chemistry and Biochemistry > Collection of Czechoslovak Chemical Communications
Journal or Publication Title:Collection of Czechoslovak Chemical Communications
Volume:64
Number:8
Page Range:pp. 1211-1252
ISSN:0010-0765
E-ISSN:1212-6950
Publisher:Institute of Organic Chemistry and Biochemistry
Related URLs:
URLURL Type
http://dx.doi.org/10.1135/cccc19991211UNSPECIFIED
ID Code:1551
Item Type:Article
Deposited On:06 Feb 2009 17:10
Last Modified:06 Feb 2009 16:10

Citation

Hlaváček, Jan; Marcová, Renáta (1999) Biological Function and Chemistry of Endothelin. A Review. Collection of Czechoslovak Chemical Communications, 64 (8). pp. 1211-1252. ISSN 0010-0765

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