7-(1-Cyanobut-3-en-1-yl)-N6-[(N,N-dimethylamino)methylene]adenine as a Starting Compound for the Synthesis of α-Branched Acyclic Analogues of N7-Isomer of Adenosine

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Title:7-(1-Cyanobut-3-en-1-yl)-N6-[(N,N-dimethylamino)methylene]adenine as a Starting Compound for the Synthesis of α-Branched Acyclic Analogues of N7-Isomer of Adenosine
Creators:
Hocková, Dana
Masojídková, Milena
Holý, Antonín
Journal or Publication Title:
Collection of Czechoslovak Chemical Communications, 64, 8, pp. 1316-1324
Uncontrolled Keywords:Purines, Nucleosides, Nitriles, Antivirals, Acyclic analogues

Abstract

7-(1-Cyanobut-3-en-1-yl)-<i>N</i><sup>6</sup>-[(<i>N,N</i>-dimethylamino)methylene]adenine (<strong>2</strong>) was used as a multipurpose starting material for the synthesis of a series of&nbsp;α-branched acyclic analogues of N<sup>7</sup>-isomer of adenosine by further reactions on allyl (hydroxylation) and/or cyano group (hydrolysis, methanolysis or tetrazole formation). <p>

Title:7-(1-Cyanobut-3-en-1-yl)-N6-[(N,N-dimethylamino)methylene]adenine as a Starting Compound for the Synthesis of α-Branched Acyclic Analogues of N7-Isomer of Adenosine
Creators:
Hocková, Dana
Masojídková, Milena
Holý, Antonín
Uncontrolled Keywords:Purines, Nucleosides, Nitriles, Antivirals, Acyclic analogues
Divisions:Life and Chemical Sciences > Institute of Organic Chemistry and Biochemistry > Collection of Czechoslovak Chemical Communications
Journal or Publication Title:Collection of Czechoslovak Chemical Communications
Volume:64
Number:8
Page Range:pp. 1316-1324
ISSN:0010-0765
E-ISSN:1212-6950
Publisher:Institute of Organic Chemistry and Biochemistry
Related URLs:
URLURL Type
http://dx.doi.org/10.1135/cccc19991316UNSPECIFIED
ID Code:1558
Item Type:Article
Deposited On:06 Feb 2009 17:10
Last Modified:06 Feb 2009 16:10

Citation

Hocková, Dana; Masojídková, Milena; Holý, Antonín (1999) 7-(1-Cyanobut-3-en-1-yl)-N6-[(N,N-dimethylamino)methylene]adenine as a Starting Compound for the Synthesis of α-Branched Acyclic Analogues of N7-Isomer of Adenosine. Collection of Czechoslovak Chemical Communications, 64 (8). pp. 1316-1324. ISSN 0010-0765

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