6-(Hydroxyphenyl)imidazo[2,1-b]thiazoles as Potential Antiinflammatory Agents: Effects on Human Neutrophil Functions

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Title:6-(Hydroxyphenyl)imidazo[2,1-b]thiazoles as Potential Antiinflammatory Agents: Effects on Human Neutrophil Functions
Creators:
Andreani, Aldo
Rambaldi, Mirella
Leoni, Alberto
Locatelli, Alessandra
Morigi, Rita
Traniello, Serena
Cariani, Alessio
Rizzuti, Olivia
Spisani, Susanna
Journal or Publication Title:
Collection of Czechoslovak Chemical Communications, 65, 2, pp. 267-279
Uncontrolled Keywords:Phenols, Levamisole, Imidazo[2,1-<i>b</i>]thiazoles, Neutrophil functions, NSAIDs, Antiinflammatory agents

Abstract

Synthesis of 6-(hydroxyphenyl)imidazo[2,1-<i>b</i>]thiazoles related to levamisole from the corresponding methoxy derivatives is reported. These compounds were tested on <i>in vitro</i> neutrophil activation, namely locomotion induced by chemoattractants, superoxide generation and lysozyme degranulation triggered by agonists. These functions were evaluated after cell pulse with different concentrations of the drugs. Several derivatives showed significant inhibitory effects, in some cases more potent than the parent compound. <p>

Title:6-(Hydroxyphenyl)imidazo[2,1-b]thiazoles as Potential Antiinflammatory Agents: Effects on Human Neutrophil Functions
Creators:
Andreani, Aldo
Rambaldi, Mirella
Leoni, Alberto
Locatelli, Alessandra
Morigi, Rita
Traniello, Serena
Cariani, Alessio
Rizzuti, Olivia
Spisani, Susanna
Uncontrolled Keywords:Phenols, Levamisole, Imidazo[2,1-<i>b</i>]thiazoles, Neutrophil functions, NSAIDs, Antiinflammatory agents
Divisions:Life and Chemical Sciences > Institute of Organic Chemistry and Biochemistry > Collection of Czechoslovak Chemical Communications
Journal or Publication Title:Collection of Czechoslovak Chemical Communications
Volume:65
Number:2
Page Range:pp. 267-279
ISSN:0010-0765
E-ISSN:1212-6950
Publisher:Institute of Organic Chemistry and Biochemistry
Related URLs:
URLURL Type
http://dx.doi.org/10.1135/cccc20000267UNSPECIFIED
ID Code:1640
Item Type:Article
Deposited On:06 Feb 2009 17:11
Last Modified:06 Feb 2009 16:11

Citation

Andreani, Aldo; Rambaldi, Mirella; Leoni, Alberto; Locatelli, Alessandra; Morigi, Rita; Traniello, Serena; Cariani, Alessio; Rizzuti, Olivia; Spisani, Susanna (2000) 6-(Hydroxyphenyl)imidazo[2,1-b]thiazoles as Potential Antiinflammatory Agents: Effects on Human Neutrophil Functions. Collection of Czechoslovak Chemical Communications, 65 (2). pp. 267-279. ISSN 0010-0765

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