Heme Peroxidases: Structure, Function, Mechanism and Involvement in Activation of Carcinogens. A Review

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Title:Heme Peroxidases: Structure, Function, Mechanism and Involvement in Activation of Carcinogens. A Review
Creators:
Stiborová, Marie
Mikšanová, Markéta
Martínek, Václav
Frei, Eva
Journal or Publication Title:
Collection of Czechoslovak Chemical Communications, 65, 3, pp. 297-325
Uncontrolled Keywords:Oxidations, Prostaglandins, Enzyme structure and function, Porphyrins, Carcinogens, Peroxidases, Reaction mechanisms, Heme proteins

Abstract

Peroxidases are enzymes playing an important role in large and diverse numbers of physiological processes in organisms including human. We have attempted in this article to summarize and review the important structural and catalytic properties of principal classes of heme peroxidases as well as their biological functions. Major reactions catalyzed by these enzymes (a conventional peroxidase cycle, reactions using O<sub>2</sub> and halogenations) and their mechanism are reviewed, too. Moreover, the reaction mechanisms by which peroxidases are implicated in bioactivation of xenobiotic chemicals are presented. Numerous chemicals including protoxicants and procarcinogens are metabolized by equally numerous chemical reactions catalyzed by peroxidases. The unifying theme is the radical nature of the oxidations. The direct conventional peroxidase reaction forming reactive species is generally responsible for the activation of procarcinogenic substrates of peroxidases. The subsequent formation of a superoxide anion radical and peroxy radicals is necessary for activation of chemicals that are poor substrates for peroxidases. The significance of studies concerning the reactions catalyzed by peroxidases is underlined in the present review article. A review with 166 references.

Title:Heme Peroxidases: Structure, Function, Mechanism and Involvement in Activation of Carcinogens. A Review
Creators:
Stiborová, Marie
Mikšanová, Markéta
Martínek, Václav
Frei, Eva
Uncontrolled Keywords:Oxidations, Prostaglandins, Enzyme structure and function, Porphyrins, Carcinogens, Peroxidases, Reaction mechanisms, Heme proteins
Divisions:Life and Chemical Sciences > Institute of Organic Chemistry and Biochemistry > Collection of Czechoslovak Chemical Communications
Journal or Publication Title:Collection of Czechoslovak Chemical Communications
Volume:65
Number:3
Page Range:pp. 297-325
ISSN:0010-0765
E-ISSN:1212-6950
Publisher:Institute of Organic Chemistry and Biochemistry
Related URLs:
URLURL Type
http://dx.doi.org/10.1135/cccc20000297UNSPECIFIED
ID Code:1642
Item Type:Article
Deposited On:06 Feb 2009 17:11
Last Modified:06 Feb 2009 16:11

Citation

Stiborová, Marie; Mikšanová, Markéta; Martínek, Václav; Frei, Eva (2000) Heme Peroxidases: Structure, Function, Mechanism and Involvement in Activation of Carcinogens. A Review. Collection of Czechoslovak Chemical Communications, 65 (3). pp. 297-325. ISSN 0010-0765

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