Flow Injection Determination of Acetylsalicylic Acid in Pharmaceutical Preparations with an Amperometric Detector

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Title:Flow Injection Determination of Acetylsalicylic Acid in Pharmaceutical Preparations with an Amperometric Detector
Creators:
Garrido, Jorge M. P. J.
Lima, José L. F. C.
Matos, Cristina D.
Journal or Publication Title:
Collection of Czechoslovak Chemical Communications, 65, 6, pp. 954-962
Uncontrolled Keywords:FIA, Pharmaceutical preparations, Electrochemistry, Acetylsalicylic acid, Amperometric detection

Abstract

This paper reports on an automated method based on a flow injection analysis single stream system with amperometric detection for the determination of acetylsalicylic acid in pharmaceutical preparations. The amperometric detection is based on the measurement at 0.8 V <i>vs</i> Ag/AgCl of the current generated when the acetylsalicylic acid hydrolysis product, salicylic acid, is oxidised at a glassy carbon electrode. The current produced is directly related to the concentration of the electroactive specie and the salicylic acid content is proportional to the level of acetylsalicylic acid present in the sample, thus it is possible to determine the concentration of acetylsalicylic acid electrochemically. This system allows a sampling rate of 150 samples per hour without requiring any pre-treatment, apart from dissolving them in a NaOH/KCl buffer, pH 13.0. The results obtained were compared with those obtained using reference methods and demonstrated excellent agreement with relative deviation always lower than 2%. <p>

Title:Flow Injection Determination of Acetylsalicylic Acid in Pharmaceutical Preparations with an Amperometric Detector
Creators:
Garrido, Jorge M. P. J.
Lima, José L. F. C.
Matos, Cristina D.
Uncontrolled Keywords:FIA, Pharmaceutical preparations, Electrochemistry, Acetylsalicylic acid, Amperometric detection
Divisions:Life and Chemical Sciences > Institute of Organic Chemistry and Biochemistry > Collection of Czechoslovak Chemical Communications
Journal or Publication Title:Collection of Czechoslovak Chemical Communications
Volume:65
Number:6
Page Range:pp. 954-962
ISSN:0010-0765
E-ISSN:1212-6950
Publisher:Institute of Organic Chemistry and Biochemistry
Related URLs:
URLURL Type
http://dx.doi.org/10.1135/cccc20000954UNSPECIFIED
ID Code:1690
Item Type:Article
Deposited On:06 Feb 2009 17:11
Last Modified:06 Feb 2009 16:11

Citation

Garrido, Jorge M. P. J.; Lima, José L. F. C.; Matos, Cristina D. (2000) Flow Injection Determination of Acetylsalicylic Acid in Pharmaceutical Preparations with an Amperometric Detector. Collection of Czechoslovak Chemical Communications, 65 (6). pp. 954-962. ISSN 0010-0765

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