Comparative Electrochemical Study of Some Phenothiazines with Carbon Paste, Solid Carbon Paste and Glass-Like Carbon Electrodes

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Title:Comparative Electrochemical Study of Some Phenothiazines with Carbon Paste, Solid Carbon Paste and Glass-Like Carbon Electrodes
Creators:
Sandulescu, Robert V.
Mirel, Simona M.
Oprean, Radu N.
Lotrean, Simion
Journal or Publication Title:
Collection of Czechoslovak Chemical Communications, 65, 6, pp. 1014-1028
Uncontrolled Keywords:Linear sweep voltammetry, Neuroleptics, Antihistaminics, Phenothiazines, Levomepromazine, Electrochemical determination, Promethazine maleate, Promazine maleate

Abstract

In order to obtain modified electrodes with phenothiazines and to develop electrochemical methods for their determination in pharmaceutical formulations, promazine maleate, promethazine maleate and levomepromazine, were studied by linear sweep voltammetry using different types of&nbsp;working electrodes: carbon paste, solid carbon paste and glass-like carbon electrodes. A comparative electrochemical study of the above mentioned pheno- thiazines was performed in aqueous-alcoholic solutions, investigating the influence of pH, ionic strength and concentration on the current-potential curves. Linear sweep voltammetry in potential range from -0.1 to +1.3 V revealed that the oxidation potential and the current, strongly depend on the type of electrode and pH, the best results being obtained in acid buffer (pH 1.0). The current intensity depending linearly on the concentration in the range of 2.5·10<sup>-5</sup>-5·10<sup>-4</sup> M promazine maleate, 2.5·10<sup>-5</sup>-2.5·10<sup>-4</sup> M promethazine maleate and 6.2·10<sup>-5</sup>-1.2·10<sup>-3</sup> M levomepromazine permits the development of electroanalytical methods to determine these phenothiazines in pharmaceuticals. The electrochemical determination yielded results comparable with spectrophotometric methods. Linear sweep voltammetry of carbon paste electrodes modified by incorporation of phenothiazines opens the possibility to use them as mediators in the design of some enzyme selective electrodes. <p>

Title:Comparative Electrochemical Study of Some Phenothiazines with Carbon Paste, Solid Carbon Paste and Glass-Like Carbon Electrodes
Creators:
Sandulescu, Robert V.
Mirel, Simona M.
Oprean, Radu N.
Lotrean, Simion
Uncontrolled Keywords:Linear sweep voltammetry, Neuroleptics, Antihistaminics, Phenothiazines, Levomepromazine, Electrochemical determination, Promethazine maleate, Promazine maleate
Divisions:Life and Chemical Sciences > Institute of Organic Chemistry and Biochemistry > Collection of Czechoslovak Chemical Communications
Journal or Publication Title:Collection of Czechoslovak Chemical Communications
Volume:65
Number:6
Page Range:pp. 1014-1028
ISSN:0010-0765
E-ISSN:1212-6950
Publisher:Institute of Organic Chemistry and Biochemistry
Related URLs:
URLURL Type
http://dx.doi.org/10.1135/cccc20001014UNSPECIFIED
ID Code:1695
Item Type:Article
Deposited On:06 Feb 2009 17:11
Last Modified:06 Feb 2009 16:11

Citation

Sandulescu, Robert V.; Mirel, Simona M.; Oprean, Radu N.; Lotrean, Simion (2000) Comparative Electrochemical Study of Some Phenothiazines with Carbon Paste, Solid Carbon Paste and Glass-Like Carbon Electrodes. Collection of Czechoslovak Chemical Communications, 65 (6). pp. 1014-1028. ISSN 0010-0765

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