Synthesis of Symmetrical Bis-Steroid Pyrazines Connected via D-Rings

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Title:Synthesis of Symmetrical Bis-Steroid Pyrazines Connected via D-Rings
Creators:
Černý, Ivan
Pouzar, Vladimír
Buděšínský, Miloš
Drašar, Pavel
Journal or Publication Title:
Collection of Czechoslovak Chemical Communications, 65, 10, pp. 1597-1608
Uncontrolled Keywords:Steroids, Cytostatic activity, Cephalostatin analogues, Symmetrical bis-steroid pyrazines, NMR spectroscopy

Abstract

Bis-steroid pyrazines fused through rings D of the steroid skeleton were synthesized. Methods for the preparation of the corresponding rings A fused derivatives (cephalostatin type) were checked on simple androstanes and then a symmetrical D fused analogue, 5α-androstano[16'',17''-5',6']pyrazino[2',3'-16,17]-5α-androstane-3β,3''b-diol, was prepared. Partially substituted bis-steroid pyrazines in both series were prepared and their use for the preparation of higher fused compounds was discussed. No significant cytostatic activity was found on parent bis-steroid pyrazines both A and D fused. <p>

Title:Synthesis of Symmetrical Bis-Steroid Pyrazines Connected via D-Rings
Creators:
Černý, Ivan
Pouzar, Vladimír
Buděšínský, Miloš
Drašar, Pavel
Uncontrolled Keywords:Steroids, Cytostatic activity, Cephalostatin analogues, Symmetrical bis-steroid pyrazines, NMR spectroscopy
Divisions:Life and Chemical Sciences > Institute of Organic Chemistry and Biochemistry > Collection of Czechoslovak Chemical Communications
Journal or Publication Title:Collection of Czechoslovak Chemical Communications
Volume:65
Number:10
Page Range:pp. 1597-1608
ISSN:0010-0765
E-ISSN:1212-6950
Publisher:Institute of Organic Chemistry and Biochemistry
Related URLs:
URLURL Type
http://dx.doi.org/10.1135/cccc20001597UNSPECIFIED
ID Code:1742
Item Type:Article
Deposited On:06 Feb 2009 17:12
Last Modified:06 Feb 2009 16:12

Citation

Černý, Ivan; Pouzar, Vladimír; Buděšínský, Miloš; Drašar, Pavel (2000) Synthesis of Symmetrical Bis-Steroid Pyrazines Connected via D-Rings. Collection of Czechoslovak Chemical Communications, 65 (10). pp. 1597-1608. ISSN 0010-0765

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