Pulse Modulation - A Novel Approach to Gradient-Based Flow Injection Techniques

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Title:Pulse Modulation - A Novel Approach to Gradient-Based Flow Injection Techniques
Creators:
Herbelin, Armando
Ruzicka, Jaromir
Journal or Publication Title:
Collection of Czechoslovak Chemical Communications, 66, 8, pp. 1219-1237
Uncontrolled Keywords:Pulse modulation, FIA, Analytical methods, Gradient, Flow injection analysis

Abstract

Development of a novel system for generation of gradients in flow injection analysis by pulse modulation is described. These user-selectable gradients are created by computer-controlled mixing of two solutions with a total volume as low as 75 μl and can be delivered under incremental or continuous flow conditions. Applications such as automated, single-standard instrument calibration are expected to benefit from high-precision linear gradients (<i>r</i><sup>2</sup> = 0.99989, <i>n</i> = 55). Gradient methods in biochemisty and immunology such as kinetic measurement of biomolecular interactions will benefit from the small volume of these gradients, especially for analytes with limited availability. <p>

Title:Pulse Modulation - A Novel Approach to Gradient-Based Flow Injection Techniques
Creators:
Herbelin, Armando
Ruzicka, Jaromir
Uncontrolled Keywords:Pulse modulation, FIA, Analytical methods, Gradient, Flow injection analysis
Divisions:Life and Chemical Sciences > Institute of Organic Chemistry and Biochemistry > Collection of Czechoslovak Chemical Communications
Journal or Publication Title:Collection of Czechoslovak Chemical Communications
Volume:66
Number:8
Page Range:pp. 1219-1237
ISSN:0010-0765
E-ISSN:1212-6950
Publisher:Institute of Organic Chemistry and Biochemistry
Related URLs:
URLURL Type
http://dx.doi.org/10.1135/cccc20011219UNSPECIFIED
ID Code:1852
Item Type:Article
Deposited On:06 Feb 2009 17:13
Last Modified:06 Feb 2009 16:13

Citation

Herbelin, Armando; Ruzicka, Jaromir (2001) Pulse Modulation - A Novel Approach to Gradient-Based Flow Injection Techniques. Collection of Czechoslovak Chemical Communications, 66 (8). pp. 1219-1237. ISSN 0010-0765

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