Synthesis of RIA Haptens: 3α,11α-Dihydroxy-5α-pregnan-20-one 11-Hemisuccinate

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Title:Synthesis of RIA Haptens: 3α,11α-Dihydroxy-5α-pregnan-20-one 11-Hemisuccinate
Creators:
Kasal, Alexander
Pásztorová, Světlana
Journal or Publication Title:
Collection of Czechoslovak Chemical Communications, 58, 3, pp. 619-628

Abstract

5α-Pregnane-3α,11α-diol-20-one (<i>XVII</i>) was prepared by hydroxylation of 5α-pregnan-3α-ol-20-one (<i>XVI</i>) by <i>Rhizopus nigricans</i> and by chemical conversion of 11α-hydroxyprogesterone (<i>I</i>). The diol <i>XVII</i> was partially acylated with 2-(trimethylsilyl)ethyl hydrogen succinate and the 11α-succinate <i>XVIII</i> was converted to the target 11α-hemisuccinate <i>XXI</i>.

Title:Synthesis of RIA Haptens: 3α,11α-Dihydroxy-5α-pregnan-20-one 11-Hemisuccinate
Creators:
Kasal, Alexander
Pásztorová, Světlana
Divisions:Life and Chemical Sciences > Institute of Organic Chemistry and Biochemistry > Collection of Czechoslovak Chemical Communications
Journal or Publication Title:Collection of Czechoslovak Chemical Communications
Volume:58
Number:3
Page Range:pp. 619-628
ISSN:0010-0765
E-ISSN:1212-6950
Publisher:Institute of Organic Chemistry and Biochemistry
Related URLs:
URLURL Type
http://dx.doi.org/10.1135/cccc19930619UNSPECIFIED
ID Code:186
Item Type:Article
Deposited On:06 Feb 2009 16:58
Last Modified:06 Feb 2009 15:59

Citation

Kasal, Alexander; Pásztorová, Světlana (1993) Synthesis of RIA Haptens: 3α,11α-Dihydroxy-5α-pregnan-20-one 11-Hemisuccinate. Collection of Czechoslovak Chemical Communications, 58 (3). pp. 619-628. ISSN 0010-0765

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