Simple NMR Determination of 5α/5β Configuration of 3-Oxosteroids

[img]PDF - Authorized users only
Language: English
180Kb
Title:Simple NMR Determination of 5α/5β Configuration of 3-Oxosteroids
Creators:
Chodounská, Hana
Buděšínský, Miloš
Šídová, Romana
Šíša, Miroslav
Kasal, Alexander
Kohout, Ladislav
Journal or Publication Title:
Collection of Czechoslovak Chemical Communications, 66, 10, pp. 1529-1544
Uncontrolled Keywords:Absolute configuration, 5α- and 5β-configuration, Steroids, Ketones, Cyclohexanes, 3-Oxosteroids, NMR spectroscopy

Abstract

A simple method to distinguish the 5α- from the 5β-isomers of 3-oxosteroids based on low-frequency <sup>1</sup>H NMR spectra was proposed. Additional <sup>1</sup>H and <sup>13</sup>C NMR characteristics were derived from the comparison of completely assigned spectra of the 5α- and 5β-isomers. The effect of substitution at different positions of steroid skeleton was evaluated on a series of isomeric 3-oxosteroids, prepared for this purpose. <p>

Title:Simple NMR Determination of 5α/5β Configuration of 3-Oxosteroids
Creators:
Chodounská, Hana
Buděšínský, Miloš
Šídová, Romana
Šíša, Miroslav
Kasal, Alexander
Kohout, Ladislav
Uncontrolled Keywords:Absolute configuration, 5α- and 5β-configuration, Steroids, Ketones, Cyclohexanes, 3-Oxosteroids, NMR spectroscopy
Divisions:Life and Chemical Sciences > Institute of Organic Chemistry and Biochemistry > Collection of Czechoslovak Chemical Communications
Journal or Publication Title:Collection of Czechoslovak Chemical Communications
Volume:66
Number:10
Page Range:pp. 1529-1544
ISSN:0010-0765
E-ISSN:1212-6950
Publisher:Institute of Organic Chemistry and Biochemistry
Related URLs:
URLURL Type
http://dx.doi.org/10.1135/cccc20011529UNSPECIFIED
ID Code:1876
Item Type:Article
Deposited On:06 Feb 2009 17:13
Last Modified:06 Feb 2009 16:13

Citation

Chodounská, Hana; Buděšínský, Miloš; Šídová, Romana; Šíša, Miroslav; Kasal, Alexander; Kohout, Ladislav (2001) Simple NMR Determination of 5α/5β Configuration of 3-Oxosteroids. Collection of Czechoslovak Chemical Communications, 66 (10). pp. 1529-1544. ISSN 0010-0765

Repository Staff Only: item control page