DC Polarographic and UV Spectrometric Studies of Substituted Furo[3,2-b]- and Furo[2,3-b]pyrroles

[img]PDF - Authorized users only
Language: English
72Kb
Title:DC Polarographic and UV Spectrometric Studies of Substituted Furo[3,2-b]- and Furo[2,3-b]pyrroles
Creators:
Romanová, Darina
Vachálková, Anna
Horváthová, Katarína
Krutošíková, Alžbeta
Journal or Publication Title:
Collection of Czechoslovak Chemical Communications, 66, 11, pp. 1615-1622
Uncontrolled Keywords:Fused heterocycles, Pyrroles, Ionization constants, DC polarography, Furans, Furo[2,3-<i>b</i>]pyrroles, UV spectroscopy, Carcinogens, Furo[3,2-<i>b</i>]pyrroles, Electroreductions

Abstract

The aim of the synthesis of substituted furo[3,2-<i>b</i>]- and furo[2,3-<i>b</i>]pyrroles was to discover biologically active compounds. On that account, their potential carcinogenicity was tested by DC polarographic assay in the presence of α-lipoic acid. Only one of the studied compounds showed a marginal carcinogenic activity, the other exhibited only a negligible carcinogenic potential under the conditions studied. Their apparent ionization constants, determined by spectrometric titration, were correlated with their structure. The results confirm that the presence of methyl, furyl and/or phenyl groups affects the ionization. <p>

Title:DC Polarographic and UV Spectrometric Studies of Substituted Furo[3,2-b]- and Furo[2,3-b]pyrroles
Creators:
Romanová, Darina
Vachálková, Anna
Horváthová, Katarína
Krutošíková, Alžbeta
Uncontrolled Keywords:Fused heterocycles, Pyrroles, Ionization constants, DC polarography, Furans, Furo[2,3-<i>b</i>]pyrroles, UV spectroscopy, Carcinogens, Furo[3,2-<i>b</i>]pyrroles, Electroreductions
Divisions:Life and Chemical Sciences > Institute of Organic Chemistry and Biochemistry > Collection of Czechoslovak Chemical Communications
Journal or Publication Title:Collection of Czechoslovak Chemical Communications
Volume:66
Number:11
Page Range:pp. 1615-1622
ISSN:0010-0765
E-ISSN:1212-6950
Publisher:Institute of Organic Chemistry and Biochemistry
Related URLs:
URLURL Type
http://dx.doi.org/10.1135/cccc20011615UNSPECIFIED
ID Code:1880
Item Type:Article
Deposited On:06 Feb 2009 17:13
Last Modified:06 Feb 2009 16:13

Citation

Romanová, Darina; Vachálková, Anna; Horváthová, Katarína; Krutošíková, Alžbeta (2001) DC Polarographic and UV Spectrometric Studies of Substituted Furo[3,2-b]- and Furo[2,3-b]pyrroles. Collection of Czechoslovak Chemical Communications, 66 (11). pp. 1615-1622. ISSN 0010-0765

Repository Staff Only: item control page