Synthesis of cis and trans Isomers of D-Ring Linked Bis-Steroid Pyrazines from 16α-Bromo-17-oxosteroids

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Title:Synthesis of cis and trans Isomers of D-Ring Linked Bis-Steroid Pyrazines from 16α-Bromo-17-oxosteroids
Creators:
Łotowski, Zenon
Morzycki, Jacek W.
Niewczas, Izabella S.
Zdanowicz, Marta
Journal or Publication Title:
Collection of Czechoslovak Chemical Communications, 67, 1, pp. 47-54
Uncontrolled Keywords:Steroids, Bis-steroidal pyrazines, Enamines, Cephalostatin analogs, α-Bromo ketones

Abstract

Treatment of 16α-bromo-17-oxosteroids <strong>1</strong> and <strong>2</strong> with gaseous ammonia and successive air-oxidation afforded the <i>cis</i> and <i>trans</i> isomers of D-linked bis-steroid pyrazines. Analogous reaction of 1α-bromo-4-nor-5α-cholestan-2-one (<strong>3</strong>) led to unexpected hydrolysis products. <p>

Title:Synthesis of cis and trans Isomers of D-Ring Linked Bis-Steroid Pyrazines from 16α-Bromo-17-oxosteroids
Creators:
Łotowski, Zenon
Morzycki, Jacek W.
Niewczas, Izabella S.
Zdanowicz, Marta
Uncontrolled Keywords:Steroids, Bis-steroidal pyrazines, Enamines, Cephalostatin analogs, α-Bromo ketones
Divisions:Life and Chemical Sciences > Institute of Organic Chemistry and Biochemistry > Collection of Czechoslovak Chemical Communications
Journal or Publication Title:Collection of Czechoslovak Chemical Communications
Volume:67
Number:1
Page Range:pp. 47-54
ISSN:0010-0765
E-ISSN:1212-6950
Publisher:Institute of Organic Chemistry and Biochemistry
Related URLs:
URLURL Type
http://dx.doi.org/10.1135/cccc20020047UNSPECIFIED
ID Code:1904
Item Type:Article
Deposited On:06 Feb 2009 17:13
Last Modified:06 Feb 2009 16:13

Citation

Łotowski, Zenon; Morzycki, Jacek W.; Niewczas, Izabella S.; Zdanowicz, Marta (2002) Synthesis of cis and trans Isomers of D-Ring Linked Bis-Steroid Pyrazines from 16α-Bromo-17-oxosteroids. Collection of Czechoslovak Chemical Communications, 67 (1). pp. 47-54. ISSN 0010-0765

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