Syntheses of Dexamethasone Conjugates of the Phytohormones Gibberellin A3 and 24-Epicastasterone

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Title:Syntheses of Dexamethasone Conjugates of the Phytohormones Gibberellin A3 and 24-Epicastasterone
Creators:
Kolbe, Adelheid
Kramell, Robert
Porzel, Andrea
Schmidt, Jürgen
Schneider, Gernot
Adam, Günter
Journal or Publication Title:
Collection of Czechoslovak Chemical Communications, 67, 1, pp. 103-114
Uncontrolled Keywords:Gibberellins, Gibberellin A<sub>3</sub>, Dexamethasone, Conjugation, Steroids, Phytohormones, 24-Epicastasterone, Brassinosteroids

Abstract

The syntheses of <i>N</i>-[10-(9α-fluoro-11β,17α-dihydroxy-16α-methyl-3-oxoandrosta-1,4-diene-17β-carboxamido)decyl]gibberellamide (<strong>7</strong>) and 6-[({<i>N</i>-[10-(9α-fluoro-11β,17α-dihydroxy- 16α-methyl-3-oxoandrosta-1,4-diene-17β-carboxamido)decyl]carbamoyl}methoxy)imino]-24-epicastasterone (<strong>10</strong>) are described. [(Benzotriazol-1-yl)oxy]bis(pyrrolidin-1-yl)methylium hexafluorophosphate (HBPyU) was used as the coupling agent for the reaction of gibberellic acid as well as of 24-epicastasterone-<i>O</i>-(carboxymethyl)oxime with <i>N</i>-(10-aminodecyl)- 9α-fluoro-11β,17α-dihydroxy-16α-methyl-3-oxoandrosta-1,4-diene-17β-carboxamide (<strong>4</strong>). The gibberellic acid conjugate <strong>7</strong> was also synthesised by the coupling of succinimidyl gibberellate <strong>6</strong> with amine <strong>4</strong>. <p>

Title:Syntheses of Dexamethasone Conjugates of the Phytohormones Gibberellin A3 and 24-Epicastasterone
Creators:
Kolbe, Adelheid
Kramell, Robert
Porzel, Andrea
Schmidt, Jürgen
Schneider, Gernot
Adam, Günter
Uncontrolled Keywords:Gibberellins, Gibberellin A<sub>3</sub>, Dexamethasone, Conjugation, Steroids, Phytohormones, 24-Epicastasterone, Brassinosteroids
Divisions:Life and Chemical Sciences > Institute of Organic Chemistry and Biochemistry > Collection of Czechoslovak Chemical Communications
Journal or Publication Title:Collection of Czechoslovak Chemical Communications
Volume:67
Number:1
Page Range:pp. 103-114
ISSN:0010-0765
E-ISSN:1212-6950
Publisher:Institute of Organic Chemistry and Biochemistry
Related URLs:
URLURL Type
http://dx.doi.org/10.1135/cccc20020103UNSPECIFIED
ID Code:1909
Item Type:Article
Deposited On:06 Feb 2009 17:13
Last Modified:06 Feb 2009 16:13

Citation

Kolbe, Adelheid; Kramell, Robert; Porzel, Andrea; Schmidt, Jürgen; Schneider, Gernot; Adam, Günter (2002) Syntheses of Dexamethasone Conjugates of the Phytohormones Gibberellin A3 and 24-Epicastasterone. Collection of Czechoslovak Chemical Communications, 67 (1). pp. 103-114. ISSN 0010-0765

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