Cardenamides from Cardenolides: Cardiac and Anticancer Activities

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Title:Cardenamides from Cardenolides: Cardiac and Anticancer Activities
Creators:
Megges, Rudolf
Weiland, Jürgen
Schön, Rudolf
Repke, Heinrich
Repke, Kurt R. H.
Journal or Publication Title:
Collection of Czechoslovak Chemical Communications, 67, 3, pp. 336-352
Uncontrolled Keywords:Cardenolides, Lactams, Steroids, Anticancer activity, Cardenamides, Na<sup>+</sup>/K<sup>+</sup>-ATPase inhibition, 21-Oxocardenamides

Abstract

Two ways are shown to transform cardioactive cardenolides into cardenamides [17β-(5-oxo-2,5-dihydropyrrol-3-yl)-5β,14β-androstane derivatives], and their derivatives by replacement of their ring oxygen by N-R. Cardioactivity is strongly decreased by this transformation. The comparatively easily accessible 21-oxocardenamides [17β-(2-maleimidyl)steroids] are strongly thiol reactive and show remarkable anticancer activity. <p>

Title:Cardenamides from Cardenolides: Cardiac and Anticancer Activities
Creators:
Megges, Rudolf
Weiland, Jürgen
Schön, Rudolf
Repke, Heinrich
Repke, Kurt R. H.
Uncontrolled Keywords:Cardenolides, Lactams, Steroids, Anticancer activity, Cardenamides, Na<sup>+</sup>/K<sup>+</sup>-ATPase inhibition, 21-Oxocardenamides
Divisions:Life and Chemical Sciences > Institute of Organic Chemistry and Biochemistry > Collection of Czechoslovak Chemical Communications
Journal or Publication Title:Collection of Czechoslovak Chemical Communications
Volume:67
Number:3
Page Range:pp. 336-352
ISSN:0010-0765
E-ISSN:1212-6950
Publisher:Institute of Organic Chemistry and Biochemistry
Related URLs:
URLURL Type
http://dx.doi.org/10.1135/cccc20020336UNSPECIFIED
ID Code:1926
Item Type:Article
Deposited On:06 Feb 2009 17:14
Last Modified:06 Feb 2009 16:14

Citation

Megges, Rudolf; Weiland, Jürgen; Schön, Rudolf; Repke, Heinrich; Repke, Kurt R. H. (2002) Cardenamides from Cardenolides: Cardiac and Anticancer Activities. Collection of Czechoslovak Chemical Communications, 67 (3). pp. 336-352. ISSN 0010-0765

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