Convenient Preparation of 2-Phenylethyl 3,3-Difluoro-2-methylpropionate

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Title:Convenient Preparation of 2-Phenylethyl 3,3-Difluoro-2-methylpropionate
Creators:
Yamazaki, Takashi
Ichige, Tatsuro
Kitazume, Tomoya
Journal or Publication Title:
Collection of Czechoslovak Chemical Communications, 67, 10, pp. 1479-1485
Uncontrolled Keywords:Dehydrofluorination, <i>Ab initio</i> calculations, Fluorine, α,β-Unsaturated esters, Hydrogenations, Fluorinated compounds

Abstract

The slow inverse addition of an LDA solution at -78 °C to an ester of 2-(trifluoromethyl)acrylic acid enabled efficient dehydrofluorination. Hydrogenation of the resulting difluoromethylacrylate furnished the target ester of 3,3-difluoro-2-methylpropionic acid in good overall yield. <p>

Title:Convenient Preparation of 2-Phenylethyl 3,3-Difluoro-2-methylpropionate
Creators:
Yamazaki, Takashi
Ichige, Tatsuro
Kitazume, Tomoya
Uncontrolled Keywords:Dehydrofluorination, <i>Ab initio</i> calculations, Fluorine, α,β-Unsaturated esters, Hydrogenations, Fluorinated compounds
Divisions:Life and Chemical Sciences > Institute of Organic Chemistry and Biochemistry > Collection of Czechoslovak Chemical Communications
Journal or Publication Title:Collection of Czechoslovak Chemical Communications
Volume:67
Number:10
Page Range:pp. 1479-1485
ISSN:0010-0765
E-ISSN:1212-6950
Publisher:Institute of Organic Chemistry and Biochemistry
Related URLs:
URLURL Type
http://dx.doi.org/10.1135/cccc20021479UNSPECIFIED
ID Code:2008
Item Type:Article
Deposited On:06 Feb 2009 17:14
Last Modified:06 Feb 2009 16:14

Citation

Yamazaki, Takashi; Ichige, Tatsuro; Kitazume, Tomoya (2002) Convenient Preparation of 2-Phenylethyl 3,3-Difluoro-2-methylpropionate. Collection of Czechoslovak Chemical Communications, 67 (10). pp. 1479-1485. ISSN 0010-0765

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