Artificial Chemistry and Molecular Darwinian Evolution in silico

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Title:Artificial Chemistry and Molecular Darwinian Evolution in silico
Creators:
Kvasnička, Vladimír
Pospíchal, Jiří
Journal or Publication Title:
Collection of Czechoslovak Chemical Communications, 68, 1, pp. 139-177
Uncontrolled Keywords:Artificial chemistry, Neutral mutations, Fitness landscape, Eigen theory of replicators, Artificial life, Molecular Darwinian evolution, Neutral evolution

Abstract

A simplified model of Darwinian evolution at the molecular level is studied by applying the methods of artificial chemistry. A chemical reactor (chemostat) contains molecules that are represented by binary strings, the strings being capable of replication with a probability proportional to their fitness. Moreover, the process of replication is not fully precise, sporadic mutations may produce new offspring strings, which are slightly different from their parent templates. The dynamics of such an autoreplicating system is described by Eigen's differential equations. These equations have a unique asymptotically stable state, which corresponds to those strings that have the highest rate constants (fitness). Fitness of binary string is calculated as a graph-theory similarity between a folding (phenotype) of respective string and the so-called required folding. The presented method offers a detailed view of mechanisms of the molecular Darwinian evolution, in particular of the meaning and importance of neutral mutations. <p>

Title:Artificial Chemistry and Molecular Darwinian Evolution in silico
Creators:
Kvasnička, Vladimír
Pospíchal, Jiří
Uncontrolled Keywords:Artificial chemistry, Neutral mutations, Fitness landscape, Eigen theory of replicators, Artificial life, Molecular Darwinian evolution, Neutral evolution
Divisions:Life and Chemical Sciences > Institute of Organic Chemistry and Biochemistry > Collection of Czechoslovak Chemical Communications
Journal or Publication Title:Collection of Czechoslovak Chemical Communications
Volume:68
Number:1
Page Range:pp. 139-177
ISSN:0010-0765
E-ISSN:1212-6950
Publisher:Institute of Organic Chemistry and Biochemistry
Related URLs:
URLURL Type
http://dx.doi.org/10.1135/cccc20030139UNSPECIFIED
ID Code:2050
Item Type:Article
Deposited On:06 Feb 2009 17:15
Last Modified:06 Feb 2009 16:15

Citation

Kvasnička, Vladimír; Pospíchal, Jiří (2003) Artificial Chemistry and Molecular Darwinian Evolution in silico. Collection of Czechoslovak Chemical Communications, 68 (1). pp. 139-177. ISSN 0010-0765

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