Circular Dichroism and Conformation of Oostatic Peptides: The Carrier-Like Role of C-Terminal Oligoproline Sequence

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Title:Circular Dichroism and Conformation of Oostatic Peptides: The Carrier-Like Role of C-Terminal Oligoproline Sequence
Creators:
Maloň, Petr
Dlouhá, Helena
Bennettová, Blanka
Tykva, Richard
Hlaváček, Jan
Journal or Publication Title:
Collection of Czechoslovak Chemical Communications, 68, 7, pp. 1309-1318
Uncontrolled Keywords:Peptides, Conformation analysis, CD spectroscopy, Hormones, Proline, Oostatic factors

Abstract

Circular dichroism spectra of the peptides H-Tyr-Asp-Pro-OH, H-Tyr-Asp-Pro-Ala-OH, H-Tyr-Asp-Pro-Ala-(Pro)<i><sub>n</sub></i>-OH (<i>n</i> = 1-6) and of their two methyleneoxy isosters were measured and analyzed in terms of possible interactions between the N-terminal (mostly tetrapeptide) part that is responsible for the oostatic activity and the C-terminal oligoproline sequence. The results indicate that the two parts are largely independent and that the C-terminal (Pro)<i><sub>n</sub></i> sequence serves another purpose, possibly as a carrier. <p>

Title:Circular Dichroism and Conformation of Oostatic Peptides: The Carrier-Like Role of C-Terminal Oligoproline Sequence
Creators:
Maloň, Petr
Dlouhá, Helena
Bennettová, Blanka
Tykva, Richard
Hlaváček, Jan
Uncontrolled Keywords:Peptides, Conformation analysis, CD spectroscopy, Hormones, Proline, Oostatic factors
Divisions:Life and Chemical Sciences > Institute of Organic Chemistry and Biochemistry > Collection of Czechoslovak Chemical Communications
Journal or Publication Title:Collection of Czechoslovak Chemical Communications
Volume:68
Number:7
Page Range:pp. 1309-1318
ISSN:0010-0765
E-ISSN:1212-6950
Publisher:Institute of Organic Chemistry and Biochemistry
Related URLs:
URLURL Type
http://dx.doi.org/10.1135/cccc20031309UNSPECIFIED
ID Code:2121
Item Type:Article
Deposited On:06 Feb 2009 17:15
Last Modified:06 Feb 2009 16:15

Citation

Maloň, Petr; Dlouhá, Helena; Bennettová, Blanka; Tykva, Richard; Hlaváček, Jan (2003) Circular Dichroism and Conformation of Oostatic Peptides: The Carrier-Like Role of C-Terminal Oligoproline Sequence. Collection of Czechoslovak Chemical Communications, 68 (7). pp. 1309-1318. ISSN 0010-0765

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