Synthesis and Calcium Antagonist Activity of Dialkyl 1,4-Dihydro-2,6-dimethyl-4-(nitrogenous heteroaryl)-3,5-pyridine Dicarboxylates

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Title:Synthesis and Calcium Antagonist Activity of Dialkyl 1,4-Dihydro-2,6-dimethyl-4-(nitrogenous heteroaryl)-3,5-pyridine Dicarboxylates
Creators:
Baraldi, Pier G.
Budriesi, Roberta
Cacciari, Barbara
Chiarini, Alberto
Garuti, Laura
Giovanninetti, Giuseppe
Leoni, Alberto
Roberti, Marinella
Journal or Publication Title:
Collection of Czechoslovak Chemical Communications, 57, 1, pp. 169-178

Abstract

A new series of 4-(nitrogenous heteroaryl)-1,4-dihydropyridine antagonists <i>II - XVI</i> were synthesized and screened for inotropic, chronotropic and calcium antagonist properties, in order to evaluate the effect on pharmacological activity of replacement of the 4-aryl group of nifedipine-like drugs by heterocyclic moieties, such as quinoline, indole, carbazole and pyrazole. The most potent bradycardic compounds of the series (<i>VIII - X</i>, <i>XII</i> and <i>XIII</i>) elicited weak calcium antagonist activity and were stronger negative inotropic.

Title:Synthesis and Calcium Antagonist Activity of Dialkyl 1,4-Dihydro-2,6-dimethyl-4-(nitrogenous heteroaryl)-3,5-pyridine Dicarboxylates
Creators:
Baraldi, Pier G.
Budriesi, Roberta
Cacciari, Barbara
Chiarini, Alberto
Garuti, Laura
Giovanninetti, Giuseppe
Leoni, Alberto
Roberti, Marinella
Divisions:Life and Chemical Sciences > Institute of Organic Chemistry and Biochemistry > Collection of Czechoslovak Chemical Communications
Journal or Publication Title:Collection of Czechoslovak Chemical Communications
Volume:57
Number:1
Page Range:pp. 169-178
ISSN:0010-0765
E-ISSN:1212-6950
Publisher:Institute of Organic Chemistry and Biochemistry
Related URLs:
URLURL Type
http://dx.doi.org/10.1135/cccc19920169UNSPECIFIED
ID Code:22
Item Type:Article
Deposited On:06 Feb 2009 16:35
Last Modified:09 Aug 2013 09:31

Citation

Baraldi, Pier G.; Budriesi, Roberta; Cacciari, Barbara; Chiarini, Alberto; Garuti, Laura; Giovanninetti, Giuseppe; Leoni, Alberto; Roberti, Marinella (1992) Synthesis and Calcium Antagonist Activity of Dialkyl 1,4-Dihydro-2,6-dimethyl-4-(nitrogenous heteroaryl)-3,5-pyridine Dicarboxylates. Collection of Czechoslovak Chemical Communications, 57 (1). pp. 169-178. ISSN 0010-0765

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