Non-Cottrell Behavior of the Dopamine Redox Reaction Observed on the Carbon Fibre Microelectrode by the Double-Step Voltcoulometry

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Title:Non-Cottrell Behavior of the Dopamine Redox Reaction Observed on the Carbon Fibre Microelectrode by the Double-Step Voltcoulometry
Creators:
Gmucová, Katarína
Orlický, Jozef
Pavlásek, Juraj
Journal or Publication Title:
Collection of Czechoslovak Chemical Communications, 69, 2, pp. 419-425
Uncontrolled Keywords:Supporting electrolyte, Kinetics, Electrochemistry, Carbon fibre microelectrode, Cottrell equation, Coulometry, Redox chemistry, Dopamines

Abstract

The redox reaction of the neurotransmitter dopamine at the carbon fibre microelectrode was studied by several electrochemical methods. It was found that under conditions usual in a living body, the diffusion current fullfils, within experimental errors, the behavior theoretically predicted by the Cottrell equation. Nevertheless, attention should be paid to the fact that unsupported or weakly supported conditions give rise to a non-Cottrell response of diffusion current. Moreover, similar changes were observed if the dopamine concentration was either lower such as several units of μmol l<sup>-1</sup>, or about 100 μmol l<sup>-1</sup> or higher. The non-Cottrell behavior of diffusion current involves the nonlinearity of the dopamine calibration curve obtained by pulse techniques. The present work is aimed at pointing out that such behavior of the measured data could lead to misinterpretation of the obtained dopamine concentration. Similar features could be also achieved for the other catecholamines. <p>

Title:Non-Cottrell Behavior of the Dopamine Redox Reaction Observed on the Carbon Fibre Microelectrode by the Double-Step Voltcoulometry
Creators:
Gmucová, Katarína
Orlický, Jozef
Pavlásek, Juraj
Uncontrolled Keywords:Supporting electrolyte, Kinetics, Electrochemistry, Carbon fibre microelectrode, Cottrell equation, Coulometry, Redox chemistry, Dopamines
Divisions:Life and Chemical Sciences > Institute of Organic Chemistry and Biochemistry > Collection of Czechoslovak Chemical Communications
Journal or Publication Title:Collection of Czechoslovak Chemical Communications
Volume:69
Number:2
Page Range:pp. 419-425
ISSN:0010-0765
E-ISSN:1212-6950
Publisher:Institute of Organic Chemistry and Biochemistry
Related URLs:
URLURL Type
http://dx.doi.org/10.1135/cccc20040419UNSPECIFIED
ID Code:2220
Item Type:Article
Deposited On:06 Feb 2009 17:16
Last Modified:06 Feb 2009 16:16

Citation

Gmucová, Katarína; Orlický, Jozef; Pavlásek, Juraj (2004) Non-Cottrell Behavior of the Dopamine Redox Reaction Observed on the Carbon Fibre Microelectrode by the Double-Step Voltcoulometry. Collection of Czechoslovak Chemical Communications, 69 (2). pp. 419-425. ISSN 0010-0765

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