Synthesis and Leukemia Cell Growth Inhibition of a Series of 1,3-Dithiazolylbenzene Derivatives

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Title:Synthesis and Leukemia Cell Growth Inhibition of a Series of 1,3-Dithiazolylbenzene Derivatives
Creators:
Lagoja, Irene M.
Nauwelaerts, Koen
Bal-Mahieu, Christine
Pasqualini, Michela
Bailly, Christian
Herdewijn, Piet
Journal or Publication Title:
Collection of Czechoslovak Chemical Communications, 69, 7, pp. 1491-1498
Uncontrolled Keywords:DNA-interaction, Thiazoles, Heterocycles, Hantzsch synthesis, Anticancer agents, NMR spectroscopy

Abstract

By a slightly modified Hantzsch thiazole synthesis either 1,3-bis[(thiazol-2-yl)amino]benzene derivatives <strong>2</strong> or 1,3-bis[2-iminothiazol-3(2<i>H</i>)-yl]benzene derivatives <strong>3</strong> were exclusively obtained. The compounds can be distinguished by NMR spectroscopy. Compounds <strong>2a</strong>-<strong>2d</strong> and <strong>3a</strong>-<strong>3d</strong> were evaluated for their potential antitumor activity, DNA interaction, and for their activity against DNA and RNA viruses and against HIV-1 and HIV-2. <p>

Title:Synthesis and Leukemia Cell Growth Inhibition of a Series of 1,3-Dithiazolylbenzene Derivatives
Creators:
Lagoja, Irene M.
Nauwelaerts, Koen
Bal-Mahieu, Christine
Pasqualini, Michela
Bailly, Christian
Herdewijn, Piet
Uncontrolled Keywords:DNA-interaction, Thiazoles, Heterocycles, Hantzsch synthesis, Anticancer agents, NMR spectroscopy
Divisions:Life and Chemical Sciences > Institute of Organic Chemistry and Biochemistry > Collection of Czechoslovak Chemical Communications
Journal or Publication Title:Collection of Czechoslovak Chemical Communications
Volume:69
Number:7
Page Range:pp. 1491-1498
ISSN:0010-0765
E-ISSN:1212-6950
Publisher:Institute of Organic Chemistry and Biochemistry
Related URLs:
URLURL Type
http://dx.doi.org/10.1135/cccc20041491UNSPECIFIED
ID Code:2288
Item Type:Article
Deposited On:06 Feb 2009 17:17
Last Modified:06 Feb 2009 16:17

Citation

Lagoja, Irene M.; Nauwelaerts, Koen; Bal-Mahieu, Christine; Pasqualini, Michela; Bailly, Christian; Herdewijn, Piet (2004) Synthesis and Leukemia Cell Growth Inhibition of a Series of 1,3-Dithiazolylbenzene Derivatives. Collection of Czechoslovak Chemical Communications, 69 (7). pp. 1491-1498. ISSN 0010-0765

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