Degradation Behavior of Poly(ethylene glycol) Diblock and Multiblock Polymers with Hydrolytically Degradable Ester Linkages

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Title:Degradation Behavior of Poly(ethylene glycol) Diblock and Multiblock Polymers with Hydrolytically Degradable Ester Linkages
Creators:
Braunová, Alena
Pechar, Michal
Ulbrich, Karel
Journal or Publication Title:
Collection of Czechoslovak Chemical Communications, 69, 8, pp. 1643-1656
Uncontrolled Keywords:Polymer drugs, Block copolymers, Biocompatible polymers, pH sensitivity, Protein modification, PEG, Drug release, Degradable bonds, Tumour therapy, Hydrolyses, Drug carriers

Abstract

Diblock and multiblock polymers of poly(ethylene glycol) containing degradable ester bonds between the blocks were synthesized and characterized. Monofunctional poly(ethylene glycol) (PEG 2000) was modified by aliphatic dicarboxylic acids (malonic, succinic, glutaric, maleic) to obtain monocarboxylic polymers PEG-COOH containing ester bonds. Diblock polymers (4000) were prepared by polycondensation of a diamine (ethane-1,2-diamine, L-lysine) and the semitelechelic PEG-COOH. The relationship between the structure of the linkage connecting two PEG blocks and the rate of its hydrolytic degradation was studied at pH 5.5, 7.4 and 8.0. The rate of hydrolysis of all polymers was significant already under mild alkaline conditions (pH 7.4 and 8.0) and increased with increasing pH. The ester bonds of polymers with saturated dicarboxylic acid moieties were stable at pH 5.5. However, the presence of double bond in the acid moiety substantially decreased the stability of the polymer not only in alkaline but also in acid medium. The results of this model study can be utilized in the design of biodegradable high-molecular-weight drug carriers and polymers for preparation of "stealth" systems intended for therapeutic application. <p>

Title:Degradation Behavior of Poly(ethylene glycol) Diblock and Multiblock Polymers with Hydrolytically Degradable Ester Linkages
Creators:
Braunová, Alena
Pechar, Michal
Ulbrich, Karel
Uncontrolled Keywords:Polymer drugs, Block copolymers, Biocompatible polymers, pH sensitivity, Protein modification, PEG, Drug release, Degradable bonds, Tumour therapy, Hydrolyses, Drug carriers
Divisions:Life and Chemical Sciences > Institute of Organic Chemistry and Biochemistry > Collection of Czechoslovak Chemical Communications
Journal or Publication Title:Collection of Czechoslovak Chemical Communications
Volume:69
Number:8
Page Range:pp. 1643-1656
ISSN:0010-0765
E-ISSN:1212-6950
Publisher:Institute of Organic Chemistry and Biochemistry
Related URLs:
URLURL Type
http://dx.doi.org/10.1135/cccc20041643UNSPECIFIED
ID Code:2300
Item Type:Article
Deposited On:06 Feb 2009 17:17
Last Modified:06 Feb 2009 16:17

Citation

Braunová, Alena; Pechar, Michal; Ulbrich, Karel (2004) Degradation Behavior of Poly(ethylene glycol) Diblock and Multiblock Polymers with Hydrolytically Degradable Ester Linkages. Collection of Czechoslovak Chemical Communications, 69 (8). pp. 1643-1656. ISSN 0010-0765

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