Inhibition of Biosynthesis and Biochemical Modulation of N-Acylneuraminic Acid (Biochemical Engineering of Sialoconjugates). A Review
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| Title: | Inhibition of Biosynthesis and Biochemical Modulation of N-Acylneuraminic Acid (Biochemical Engineering of Sialoconjugates). A Review |
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| Creators: | Reutter, Werner Horstkorte, Rüdiger |
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| Journal or Publication Title: | Collection of Czechoslovak Chemical Communications, 69, 10, pp. 1829-1842 |
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| Uncontrolled Keywords: | T-lymphocytes, UDP-<i>N</i>-acetylglucosamine 2-epimerase/<i>N</i>-acylmannosamine kinase inhibitors, Neurite growth, Sialyl-Lewis<sup>x</sup>, <i>N</i>-Acetylneuraminic acid, Influenza viruses, <i>N</i>-Propionylmannosamine, Sialylation, Recombinant glycoproteins, Sialic acid, <i>N</i>-Propionylneuraminic acid, Glycans |
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AbstractThe key enzyme of sialic acid biosynthesis is the bifunctional UDP-GlcNAc 2-epimerase/ ManNAc kinase. Novel inhibitors of this enzyme have been synthesized. The <i>N</i>-acyl side chain of sialic acid can be biochemically engineered by incubating cells with non-natural <i>N</i>-acylmannosamine analogues such as <i>N</i>-propionylmannosamine and related compounds. These modified sialic acids lead to various biological changes, such as stimulation of T-lymphocyte proliferation, inhibition of the uptake of influenza A virus, stimulation of neuritic growth, increased expression of sialyl-Lewis<sup>x</sup> and altered adhesion. A review with 41 references. <p> | Title: | Inhibition of Biosynthesis and Biochemical Modulation of N-Acylneuraminic Acid (Biochemical Engineering of Sialoconjugates). A Review |
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| Creators: | Reutter, Werner Horstkorte, Rüdiger |
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| Uncontrolled Keywords: | T-lymphocytes, UDP-<i>N</i>-acetylglucosamine 2-epimerase/<i>N</i>-acylmannosamine kinase inhibitors, Neurite growth, Sialyl-Lewis<sup>x</sup>, <i>N</i>-Acetylneuraminic acid, Influenza viruses, <i>N</i>-Propionylmannosamine, Sialylation, Recombinant glycoproteins, Sialic acid, <i>N</i>-Propionylneuraminic acid, Glycans |
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| Divisions: | Life and Chemical Sciences > Institute of Organic Chemistry and Biochemistry > Collection of Czechoslovak Chemical Communications |
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| Journal or Publication Title: | Collection of Czechoslovak Chemical Communications |
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| Volume: | 69 |
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| Number: | 10 |
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| Page Range: | pp. 1829-1842 |
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| ISSN: | 0010-0765 |
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| E-ISSN: | 1212-6950 |
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| Publisher: | Institute of Organic Chemistry and Biochemistry |
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| Related URLs: | |
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| ID Code: | 2308 |
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| Item Type: | Article |
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| Deposited On: | 06 Feb 2009 17:17 |
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| Last Modified: | 06 Feb 2009 16:17 |
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CitationReutter, Werner; Horstkorte, Rüdiger (2004) Inhibition of Biosynthesis and Biochemical Modulation of N-Acylneuraminic Acid (Biochemical Engineering of Sialoconjugates). A Review. Collection of Czechoslovak Chemical Communications, 69 (10). pp. 1829-1842. ISSN 0010-0765Repository Staff Only: item control page |
