Inhibition of Biosynthesis and Biochemical Modulation of N-Acylneuraminic Acid (Biochemical Engineering of Sialoconjugates). A Review

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Title:Inhibition of Biosynthesis and Biochemical Modulation of N-Acylneuraminic Acid (Biochemical Engineering of Sialoconjugates). A Review
Creators:
Reutter, Werner
Horstkorte, Rüdiger
Journal or Publication Title:
Collection of Czechoslovak Chemical Communications, 69, 10, pp. 1829-1842
Uncontrolled Keywords:T-lymphocytes, UDP-<i>N</i>-acetylglucosamine 2-epimerase/<i>N</i>-acylmannosamine kinase inhibitors, Neurite growth, Sialyl-Lewis<sup>x</sup>, <i>N</i>-Acetylneuraminic acid, Influenza viruses, <i>N</i>-Propionylmannosamine, Sialylation, Recombinant glycoproteins, Sialic acid, <i>N</i>-Propionylneuraminic acid, Glycans

Abstract

The key enzyme of sialic acid biosynthesis is the bifunctional UDP-GlcNAc 2-epimerase/ ManNAc kinase. Novel inhibitors of this enzyme have been synthesized. The <i>N</i>-acyl side chain of sialic acid can be biochemically engineered by incubating cells with non-natural <i>N</i>-acylmannosamine analogues such as <i>N</i>-propionylmannosamine and related compounds. These modified sialic acids lead to various biological changes, such as stimulation of T-lymphocyte proliferation, inhibition of the uptake of influenza A virus, stimulation of neuritic growth, increased expression of sialyl-Lewis<sup>x</sup> and altered adhesion. A review with 41 references. <p>

Title:Inhibition of Biosynthesis and Biochemical Modulation of N-Acylneuraminic Acid (Biochemical Engineering of Sialoconjugates). A Review
Creators:
Reutter, Werner
Horstkorte, Rüdiger
Uncontrolled Keywords:T-lymphocytes, UDP-<i>N</i>-acetylglucosamine 2-epimerase/<i>N</i>-acylmannosamine kinase inhibitors, Neurite growth, Sialyl-Lewis<sup>x</sup>, <i>N</i>-Acetylneuraminic acid, Influenza viruses, <i>N</i>-Propionylmannosamine, Sialylation, Recombinant glycoproteins, Sialic acid, <i>N</i>-Propionylneuraminic acid, Glycans
Divisions:Life and Chemical Sciences > Institute of Organic Chemistry and Biochemistry > Collection of Czechoslovak Chemical Communications
Journal or Publication Title:Collection of Czechoslovak Chemical Communications
Volume:69
Number:10
Page Range:pp. 1829-1842
ISSN:0010-0765
E-ISSN:1212-6950
Publisher:Institute of Organic Chemistry and Biochemistry
Related URLs:
URLURL Type
http://dx.doi.org/10.1135/cccc20041829UNSPECIFIED
ID Code:2308
Item Type:Article
Deposited On:06 Feb 2009 17:17
Last Modified:06 Feb 2009 16:17

Citation

Reutter, Werner; Horstkorte, Rüdiger (2004) Inhibition of Biosynthesis and Biochemical Modulation of N-Acylneuraminic Acid (Biochemical Engineering of Sialoconjugates). A Review. Collection of Czechoslovak Chemical Communications, 69 (10). pp. 1829-1842. ISSN 0010-0765

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