Reactivity of Free Radicals Generated from Neurotransmitters Studied by Electron Spin Resonance Spectroscopy

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Title:Reactivity of Free Radicals Generated from Neurotransmitters Studied by Electron Spin Resonance Spectroscopy
Creators:
Tkáč, Alexander
Hanušovská, Eva
Journal or Publication Title:
Collection of Czechoslovak Chemical Communications, 69, 11, pp. 2081-2090
Uncontrolled Keywords:Free radicals, Neurotransmitters, Antioxidants, Stobadine, Vitamin E, Dopamine, ESR spectroscopy

Abstract

Free phenoxy radicals derived from catecholamine-type neurotransmitters (dopamine, noradrenaline, adrenaline) σ-coordinated to Co(III) chelates were generated by the reaction of π-coordinated <i>tert</i>-butylperoxy radicals with the neurotransmitters in non-polar solvent at ambient temperature. The ESR signals of the formed complexes are split into the basic octet line resulting from the interaction of the unpaired electron of the phenoxy radical with the <sup>59</sup>Co nucleus (<i>I</i> = 7/2). Increasing the polarity of the solution starts the decomplexation and the liberated phenoxy radicals of the neurotransmitters disappear by recombination or by H-abstraction from the added antioxidant. When vitamin E is added to the system, only the ESR signal of the stable α-tocopheroxy radicals is detectable. Similarly, in the presence of the antiarrhytmic drug Stobadine, only the signal of the corresponding nitrogen-centred radical is seen. In the presence of both antioxidants, rapid H-transfer occurs from vitamin E to the Stobadine radicals. <p>

Title:Reactivity of Free Radicals Generated from Neurotransmitters Studied by Electron Spin Resonance Spectroscopy
Creators:
Tkáč, Alexander
Hanušovská, Eva
Uncontrolled Keywords:Free radicals, Neurotransmitters, Antioxidants, Stobadine, Vitamin E, Dopamine, ESR spectroscopy
Divisions:Life and Chemical Sciences > Institute of Organic Chemistry and Biochemistry > Collection of Czechoslovak Chemical Communications
Journal or Publication Title:Collection of Czechoslovak Chemical Communications
Volume:69
Number:11
Page Range:pp. 2081-2090
ISSN:0010-0765
E-ISSN:1212-6950
Publisher:Institute of Organic Chemistry and Biochemistry
Related URLs:
URLURL Type
http://dx.doi.org/10.1135/cccc20042081UNSPECIFIED
ID Code:2322
Item Type:Article
Deposited On:06 Feb 2009 17:17
Last Modified:06 Feb 2009 16:17

Citation

Tkáč, Alexander; Hanušovská, Eva (2004) Reactivity of Free Radicals Generated from Neurotransmitters Studied by Electron Spin Resonance Spectroscopy. Collection of Czechoslovak Chemical Communications, 69 (11). pp. 2081-2090. ISSN 0010-0765

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